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NHE3 inhibitor tenapanor maintains intestinal barrier function, decreases visceral hypersensitivity, and attenuates TRPV1 signaling in colonic sensory neurons.
King AJ, Chang L, Li Q, Liu L, Zhu Y, Pasricha PJ, Wang J, Siegel M, Caldwell JS, Edelstein S, Rosenbaum DP, Kozuka K. King AJ, et al. Among authors: li q. Am J Physiol Gastrointest Liver Physiol. 2024 May 1;326(5):G543-G554. doi: 10.1152/ajpgi.00233.2023. Epub 2024 Jan 22. Am J Physiol Gastrointest Liver Physiol. 2024. PMID: 38252683 Free PMC article.
Adult enteric nervous system in health is maintained by a dynamic balance between neuronal apoptosis and neurogenesis.
Kulkarni S, Micci MA, Leser J, Shin C, Tang SC, Fu YY, Liu L, Li Q, Saha M, Li C, Enikolopov G, Becker L, Rakhilin N, Anderson M, Shen X, Dong X, Butte MJ, Song H, Southard-Smith EM, Kapur RP, Bogunovic M, Pasricha PJ. Kulkarni S, et al. Among authors: li c, li q. Proc Natl Acad Sci U S A. 2017 May 2;114(18):E3709-E3718. doi: 10.1073/pnas.1619406114. Epub 2017 Apr 18. Proc Natl Acad Sci U S A. 2017. PMID: 28420791 Free PMC article.
NaV1.1 inhibition can reduce visceral hypersensitivity.
Salvatierra J, Castro J, Erickson A, Li Q, Braz J, Gilchrist J, Grundy L, Rychkov GY, Deiteren A, Rais R, King GF, Slusher BS, Basbaum A, Pasricha PJ, Brierley SM, Bosmans F. Salvatierra J, et al. Among authors: li q. JCI Insight. 2018 Jun 7;3(11):e121000. doi: 10.1172/jci.insight.121000. eCollection 2018 Jun 7. JCI Insight. 2018. PMID: 29875317 Free PMC article.
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