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Effects of a selective glucocorticoid receptor modulator (AZD9567) versus prednisolone in healthy volunteers: two phase 1, single-blind, randomised controlled trials.
Hegelund Myrbäck T, Prothon S, Edman K, Leander J, Hashemi M, Dearman M, Edenro G, Svanberg P, Andersson EM, Almquist J, Ämmälä C, Hendrickx R, Taib Z, Johansson KA, Berggren AR, Keen CM, Eriksson UG, Fuhr R, Carlsson BCL. Hegelund Myrbäck T, et al. Among authors: edman k. Lancet Rheumatol. 2020 Jan;2(1):e31-e41. doi: 10.1016/S2665-9913(19)30103-1. Epub 2019 Dec 9. Lancet Rheumatol. 2020. PMID: 38258274
AZD9567 versus prednisolone in patients with active rheumatoid arthritis: A phase IIa, randomized, double-blind, efficacy, and safety study.
van Laar JM, Lei A, Safy-Khan M, Almquist J, Belfield G, Edman K, Öberg L, Angermann BR, Dillmann I, Berntsson P, Etal D, Dainty I, Astbury C, Belvisi MG, Nemes S, Platt A, Prothon S, Samuelsson S, Svanberg P, Keen C; SEMRA study group. van Laar JM, et al. Among authors: edman k. Clin Transl Sci. 2023 Dec;16(12):2494-2506. doi: 10.1111/cts.13624. Epub 2023 Oct 23. Clin Transl Sci. 2023. PMID: 37873558 Free PMC article. Clinical Trial.
The effect of AZD9567 vs. prednisolone on glycaemic control in patients with type 2 diabetes mellitus: Results from a phase 2a clinical trial.
Ambery P, Zajac G, Almquist J, Prothon S, Astbury C, Brown MN, Nemes S, Nsabimana J, Edman K, Öberg L, Lepistö M, Edenro G, Dillmann I, Mitra S, Belfield G, Keen C, Heise T. Ambery P, et al. Among authors: edman k. Br J Clin Pharmacol. 2024 Aug;90(8):1921-1931. doi: 10.1111/bcp.16082. Epub 2024 May 1. Br J Clin Pharmacol. 2024. PMID: 38690606 Clinical Trial.
Quaternary glucocorticoid receptor structure highlights allosteric interdomain communication.
Postel S, Wissler L, Johansson CA, Gunnarsson A, Gordon E, Collins B, Castaldo M, Köhler C, Öling D, Johansson P, Fröderberg Roth L, Beinsteiner B, Dainty I, Delaney S, Klaholz BP, Billas IML, Edman K. Postel S, et al. Among authors: edman k. Nat Struct Mol Biol. 2023 Mar;30(3):286-295. doi: 10.1038/s41594-022-00914-4. Epub 2023 Feb 6. Nat Struct Mol Biol. 2023. PMID: 36747092
Correction to "Designing Selective Drug-like Molecular Glues for the Glucocorticoid Receptor/14-3-3 Protein-Protein Interaction".
Pallesen JS, Munier CC, Bosica F, Andrei SA, Edman K, Gunnarsson A, La Sala G, Putra OD, Srdanović S, Wilson AJ, Wissler L, Ottmann C, Perry MWD, O'Mahony G. Pallesen JS, et al. Among authors: edman k. J Med Chem. 2023 Feb 9;66(3):2205-2207. doi: 10.1021/acs.jmedchem.3c00076. Epub 2023 Jan 28. J Med Chem. 2023. PMID: 36708352 Free PMC article. No abstract available.
Designing Selective Drug-like Molecular Glues for the Glucocorticoid Receptor/14-3-3 Protein-Protein Interaction.
Pallesen JS, Munier CC, Bosica F, Andrei SA, Edman K, Gunnarsson A, La Sala G, Putra OD, Srdanović S, Wilson AJ, Wissler L, Ottmann C, Perry MWD, O'Mahony G. Pallesen JS, et al. Among authors: edman k. J Med Chem. 2022 Dec 22;65(24):16818-16828. doi: 10.1021/acs.jmedchem.2c01635. Epub 2022 Dec 9. J Med Chem. 2022. PMID: 36484727 Free PMC article.
178 results