Sinkunas T - Search Results

1

Innate programmable DNA binding by CRISPR-Cas12m effectors enable efficient base editing.

Bigelyte G, Duchovska B, Zedaveinyte R, Sasnauskas G, Sinkunas T, Dalgediene I, Tamulaitiene G, Silanskas A, Kazlauskas D, Valančauskas L, Madariaga-Marcos J, Seidel R, Siksnys V, Karvelis T. Bigelyte G, et al. Among authors: sinkunas t. Nucleic Acids Res. 2024 Apr 12;52(6):3234-3248. doi: 10.1093/nar/gkae016. Nucleic Acids Res. 2024. PMID: 38261981 Free PMC article.

2

The energy landscape for R-loop formation by the CRISPR-Cas Cascade complex.

Kauert DJ, Madariaga-Marcos J, Rutkauskas M, Wulfken A, Songailiene I, Sinkunas T, Siksnys V, Seidel R. Kauert DJ, et al. Among authors: sinkunas t. Nat Struct Mol Biol. 2023 Jul;30(7):1040-1047. doi: 10.1038/s41594-023-01019-2. Epub 2023 Jul 6. Nat Struct Mol Biol. 2023. PMID: 37415009

3

Dynamic interplay between target search and recognition for a Type I CRISPR-Cas system.

Aldag P, Rutkauskas M, Madariaga-Marcos J, Songailiene I, Sinkunas T, Kemmerich F, Kauert D, Siksnys V, Seidel R. Aldag P, et al. Among authors: sinkunas t. Nat Commun. 2023 Jun 20;14(1):3654. doi: 10.1038/s41467-023-38790-1. Nat Commun. 2023. PMID: 37339984 Free PMC article.

4

A quantitative model for the dynamics of target recognition and off-target rejection by the CRISPR-Cas Cascade complex.

Rutkauskas M, Songailiene I, Irmisch P, Kemmerich FE, Sinkunas T, Siksnys V, Seidel R. Rutkauskas M, et al. Among authors: sinkunas t. Nat Commun. 2022 Dec 3;13(1):7460. doi: 10.1038/s41467-022-35116-5. Nat Commun. 2022. PMID: 36460652 Free PMC article.

5

Disarming of type I-F CRISPR-Cas surveillance complex by anti-CRISPR proteins AcrIF6 and AcrIF9.

Kupcinskaite E, Tutkus M, Kopūstas A, Ašmontas S, Jankunec M, Zaremba M, Tamulaitiene G, Sinkunas T. Kupcinskaite E, et al. Among authors: sinkunas t. Sci Rep. 2022 Sep 15;12(1):15548. doi: 10.1038/s41598-022-19797-y. Sci Rep. 2022. PMID: 36109551 Free PMC article.

6

DNA interference is controlled by R-loop length in a type I-F1 CRISPR-Cas system.

Tuminauskaite D, Norkunaite D, Fiodorovaite M, Tumas S, Songailiene I, Tamulaitiene G, Sinkunas T. Tuminauskaite D, et al. Among authors: sinkunas t. BMC Biol. 2020 Jun 15;18(1):65. doi: 10.1186/s12915-020-00799-z. BMC Biol. 2020. PMID: 32539804 Free PMC article.

7

Decision-Making in Cascade Complexes Harboring crRNAs of Altered Length.

Songailiene I, Rutkauskas M, Sinkunas T, Manakova E, Wittig S, Schmidt C, Siksnys V, Seidel R. Songailiene I, et al. Among authors: sinkunas t. Cell Rep. 2019 Sep 17;28(12):3157-3166.e4. doi: 10.1016/j.celrep.2019.08.033. Cell Rep. 2019. PMID: 31533038 Free PMC article.

8

BREX system of Escherichia coli distinguishes self from non-self by methylation of a specific DNA site.

Gordeeva J, Morozova N, Sierro N, Isaev A, Sinkunas T, Tsvetkova K, Matlashov M, Truncaite L, Morgan RD, Ivanov NV, Siksnys V, Zeng L, Severinov K. Gordeeva J, et al. Among authors: sinkunas t. Nucleic Acids Res. 2019 Jan 10;47(1):253-265. doi: 10.1093/nar/gky1125. Nucleic Acids Res. 2019. PMID: 30418590 Free PMC article.

9

DnaQ exonuclease-like domain of Cas2 promotes spacer integration in a type I-E CRISPR-Cas system.

Drabavicius G, Sinkunas T, Silanskas A, Gasiunas G, Venclovas Č, Siksnys V. Drabavicius G, et al. Among authors: sinkunas t. EMBO Rep. 2018 Jul;19(7):e45543. doi: 10.15252/embr.201745543. Epub 2018 Jun 11. EMBO Rep. 2018. PMID: 29891635 Free PMC article.

10

Cas3 nuclease-helicase activity assays.

Sinkunas T, Gasiunas G, Siksnys V. Sinkunas T, et al. Methods Mol Biol. 2015;1311:277-91. doi: 10.1007/978-1-4939-2687-9_18. Methods Mol Biol. 2015. PMID: 25981480

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