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90 results

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Page 1
Genome editing with the HDR-enhancing DNA-PKcs inhibitor AZD7648 causes large-scale genomic alterations.
Cullot G, Aird EJ, Schlapansky MF, Yeh CD, van de Venn L, Vykhlyantseva I, Kreutzer S, Mailänder D, Lewków B, Klermund J, Montellese C, Biserni M, Aeschimann F, Vonarburg C, Gehart H, Cathomen T, Corn JE. Cullot G, et al. Among authors: corn je. Nat Biotechnol. 2024 Nov 27. doi: 10.1038/s41587-024-02488-6. Online ahead of print. Nat Biotechnol. 2024. PMID: 39604565
Deciphering regulation of FOXP3 expression in human conventional T cells.
Umhoefer JM, Arce MM, Dajani R, Belk JA, Mowery CT, Nguyen V, Gowen BG, Simeonov DR, Curie GL, Corn JE, Chang HY, Marson A. Umhoefer JM, et al. Among authors: corn je. bioRxiv [Preprint]. 2024 Sep 2:2024.08.30.610436. doi: 10.1101/2024.08.30.610436. bioRxiv. 2024. PMID: 39282425 Free PMC article. Preprint.
Intercellular nanotube-mediated mitochondrial transfer enhances T cell metabolic fitness and antitumor efficacy.
Baldwin JG, Heuser-Loy C, Saha T, Schelker RC, Slavkovic-Lukic D, Strieder N, Hernandez-Lopez I, Rana N, Barden M, Mastrogiovanni F, Martín-Santos A, Raimondi A, Brohawn P, Higgs BW, Gebhard C, Kapoor V, Telford WG, Gautam S, Xydia M, Beckhove P, Frischholz S, Schober K, Kontarakis Z, Corn JE, Iannacone M, Inverso D, Rehli M, Fioravanti J, Sengupta S, Gattinoni L. Baldwin JG, et al. Among authors: corn je. Cell. 2024 Nov 14;187(23):6614-6630.e21. doi: 10.1016/j.cell.2024.08.029. Epub 2024 Sep 13. Cell. 2024. PMID: 39276774 Free article.
CCAR1 promotes DNA repair via alternative splicing.
Karasu ME, Jahnke L, Joseph BJ, Amerzhanova Y, Mironov A, Shu X, Schröder MS, Gvozdenovic A, Sala I, Zavolan M, Jonas S, Corn JE. Karasu ME, et al. Among authors: corn je. Mol Cell. 2024 Jul 25;84(14):2634-2647.e9. doi: 10.1016/j.molcel.2024.06.011. Epub 2024 Jul 3. Mol Cell. 2024. PMID: 38964321 Free article.
Systematic decoding of cis gene regulation defines context-dependent control of the multi-gene costimulatory receptor locus in human T cells.
Mowery CT, Freimer JW, Chen Z, Casaní-Galdón S, Umhoefer JM, Arce MM, Gjoni K, Daniel B, Sandor K, Gowen BG, Nguyen V, Simeonov DR, Garrido CM, Curie GL, Schmidt R, Steinhart Z, Satpathy AT, Pollard KS, Corn JE, Bernstein BE, Ye CJ, Marson A. Mowery CT, et al. Among authors: corn je. Nat Genet. 2024 Jun;56(6):1156-1167. doi: 10.1038/s41588-024-01743-5. Epub 2024 May 29. Nat Genet. 2024. PMID: 38811842 Free PMC article.
Base editing of key residues in the BCL11A-XL-specific zinc finger domains derepresses fetal globin expression.
Rajendiran V, Devaraju N, Haddad M, Ravi NS, Panigrahi L, Paul J, Gopalakrishnan C, Wyman S, Ariudainambi K, Mahalingam G, Periyasami Y, Prasad K, George A, Sukumaran D, Gopinathan S, Pai AA, Nakamura Y, Balasubramanian P, Ramalingam R, Thangavel S, Velayudhan SR, Corn JE, Mackay JP, Marepally S, Srivastava A, Crossley M, Mohankumar KM. Rajendiran V, et al. Among authors: corn je. Mol Ther. 2024 Mar 6;32(3):663-677. doi: 10.1016/j.ymthe.2024.01.023. Epub 2024 Jan 24. Mol Ther. 2024. PMID: 38273654 Free article.
Epitope-engineered human hematopoietic stem cells are shielded from CD123-targeted immunotherapy.
Marone R, Landmann E, Devaux A, Lepore R, Seyres D, Zuin J, Burgold T, Engdahl C, Capoferri G, Dell'Aglio A, Larrue C, Simonetta F, Rositzka J, Rhiel M, Andrieux G, Gallagher DN, Schröder MS, Wiederkehr A, Sinopoli A, Do Sacramento V, Haydn A, Garcia-Prat L, Divsalar C, Camus A, Xu L, Bordoli L, Schwede T, Porteus M, Tamburini J, Corn JE, Cathomen T, Cornu TI, Urlinger S, Jeker LT. Marone R, et al. Among authors: corn je. J Exp Med. 2023 Dec 4;220(12):e20231235. doi: 10.1084/jem.20231235. Epub 2023 Sep 29. J Exp Med. 2023. PMID: 37773046 Free PMC article.
Engineering of the endogenous HBD promoter increases HbA2.
Boontanrart MY, Mächler E, Ponta S, Nelis JC, Preiano VG, Corn JE. Boontanrart MY, et al. Among authors: corn je. Elife. 2023 Jun 2;12:e85258. doi: 10.7554/eLife.85258. Elife. 2023. PMID: 37265399 Free PMC article.
90 results