Schutkowski M - Search Results

1

Comparative Structure-Based Virtual Screening Utilizing Optimized AlphaFold Model Identifies Selective HDAC11 Inhibitor.

Baselious F, Hilscher S, Robaa D, Barinka C, Schutkowski M, Sippl W. Baselious F, et al. Among authors: schutkowski m. Int J Mol Sci. 2024 Jan 22;25(2):1358. doi: 10.3390/ijms25021358. Int J Mol Sci. 2024. PMID: 38279359 Free PMC article.

2

Continuous Fluorescent Sirtuin Activity Assay Based on Fatty Acylated Lysines.

Zessin M, Meleshin M, Hilscher S, Schiene-Fischer C, Barinka C, Jung M, Schutkowski M. Zessin M, et al. Among authors: schutkowski m. Int J Mol Sci. 2023 Apr 18;24(8):7416. doi: 10.3390/ijms24087416. Int J Mol Sci. 2023. PMID: 37108579 Free PMC article.

3

Novel hydroxamic acid derivative induces apoptosis and constrains autophagy in leukemic cells.

Fischer MA, Mustafa AM, Hausmann K, Ashry R, Kansy AG, Liebl MC, Brachetti C, Piée-Staffa A, Zessin M, Ibrahim HS, Hofmann TG, Schutkowski M, Sippl W, Krämer OH. Fischer MA, et al. Among authors: schutkowski m. J Adv Res. 2024 Jun;60:201-214. doi: 10.1016/j.jare.2023.07.005. Epub 2023 Jul 17. J Adv Res. 2024. PMID: 37467961 Free PMC article.

4

Application of Ligand- and Structure-Based Prediction Models for the Design of Alkylhydrazide-Based HDAC3 Inhibitors as Novel Anti-Cancer Compounds.

Bülbül EF, Robaa D, Sun P, Mahmoudi F, Melesina J, Zessin M, Schutkowski M, Sippl W. Bülbül EF, et al. Among authors: schutkowski m. Pharmaceuticals (Basel). 2023 Jul 6;16(7):968. doi: 10.3390/ph16070968. Pharmaceuticals (Basel). 2023. PMID: 37513880 Free PMC article.

5

Epigenetic-based differentiation therapy for Acute Myeloid Leukemia.

San José-Enériz E, Gimenez-Camino N, Rabal O, Garate L, Miranda E, Gómez-Echarte N, García F, Charalampopoulou S, Sáez E, Vilas-Zornoza A, San Martín-Uriz P, Valcárcel LV, Barrena N, Alignani D, Tamariz-Amador LE, Pérez-Ruiz A, Hilscher S, Schutkowski M, Alfonso-Pierola A, Martinez-Calle N, Larrayoz MJ, Paiva B, Calasanz MJ, Muñoz J, Isasa M, Martin-Subero JI, Pineda-Lucena A, Oyarzabal J, Agirre X, Prósper F. San José-Enériz E, et al. Among authors: schutkowski m. Nat Commun. 2024 Jul 2;15(1):5570. doi: 10.1038/s41467-024-49784-y. Nat Commun. 2024. PMID: 38956053 Free PMC article.

6

Utilization of an optimized AlphaFold protein model for structure-based design of a selective HDAC11 inhibitor with anti-neuroblastoma activity.

Baselious F, Hilscher S, Hagemann S, Tripathee S, Robaa D, Barinka C, Hüttelmaier S, Schutkowski M, Sippl W. Baselious F, et al. Among authors: schutkowski m. Arch Pharm (Weinheim). 2024 Oct;357(10):e2400486. doi: 10.1002/ardp.202400486. Epub 2024 Jul 12. Arch Pharm (Weinheim). 2024. PMID: 38996352

7

Probing class I histone deacetylases (HDAC) with proteolysis targeting chimera (PROTAC) for the development of highly potent and selective degraders.

Ibrahim HS, Guo M, Hilscher S, Erdmann F, Schmidt M, Schutkowski M, Sheng C, Sippl W. Ibrahim HS, et al. Among authors: schutkowski m. Bioorg Chem. 2024 Dec;153:107887. doi: 10.1016/j.bioorg.2024.107887. Epub 2024 Oct 12. Bioorg Chem. 2024. PMID: 39423771 Free article.

8

Dona Flor and her two husbands: Discovery of novel HDAC6/AKT2 inhibitors for myeloid cancer treatment.

Waitman KB, Martin HJ, Carlos JAEG, Braga RC, Souza VAM, Melo-Filho CC, Hilscher S, Toledo MFZJ, Tavares MT, Costa-Lotufo LV, Machado-Neto JA, Schutkowski M, Sippl W, Kronenberger T, Alves VM, Parise-Filho R, Muratov EN. Waitman KB, et al. Among authors: schutkowski m. bioRxiv [Preprint]. 2024 Dec 5:2024.11.30.626092. doi: 10.1101/2024.11.30.626092. bioRxiv. 2024. PMID: 39677737 Free PMC article. Preprint.

9

Synthesis of Complex Thiazoline-Containing Peptides by Cyclodesulfhydration of N-Thioacyl-2-Mercaptoethylamine Derivatives.

Meleshin M, Koch L, Wiedemann C, Schutkowski M. Meleshin M, et al. Among authors: schutkowski m. Angew Chem Int Ed Engl. 2023 Jun 19;62(25):e202301543. doi: 10.1002/anie.202301543. Epub 2023 May 11. Angew Chem Int Ed Engl. 2023. PMID: 37029095

10

Development of new pyrazoles as class I HDAC inhibitors: Synthesis, molecular modeling, and biological characterization in leukemia cells.

Berluti F, Baselious F, Hagemann S, Hilscher S, Schmidt M, Hüttelmaier S, Schutkowski M, Sippl W, Ibrahim HS. Berluti F, et al. Among authors: schutkowski m. Arch Pharm (Weinheim). 2024 Nov;357(11):e2400437. doi: 10.1002/ardp.202400437. Epub 2024 Sep 18. Arch Pharm (Weinheim). 2024. PMID: 39291901

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