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Loss of Pip4k2c confers liver-metastatic organotropism through insulin-dependent PI3K-AKT pathway activation.
Rogava M, Aprati TJ, Chi WY, Melms JC, Hug C, Davis SH, Earlie EM, Chung C, Deshmukh SK, Wu S, Sledge G, Tang S, Ho P, Amin AD, Caprio L, Gurjao C, Tagore S, Ngo B, Lee MJ, Zanetti G, Wang Y, Chen S, Ge W, Melo LMN, Allies G, Rösler J, Gibney GT, Schmitz OJ, Sykes M, Creusot RJ, Tüting T, Schadendorf D, Röcken M, Eigentler TK, Molotkov A, Mintz A, Bakhoum SF, Beyaz S, Cantley LC, Sorger PK, Meckelmann SW, Tasdogan A, Liu D, Laughney AM, Izar B. Rogava M, et al. Among authors: lee mj. Nat Cancer. 2024 Mar;5(3):433-447. doi: 10.1038/s43018-023-00704-x. Epub 2024 Jan 29. Nat Cancer. 2024. PMID: 38286827 Free PMC article.
The bromodomain protein Brd4 insulates chromatin from DNA damage signalling.
Floyd SR, Pacold ME, Huang Q, Clarke SM, Lam FC, Cannell IG, Bryson BD, Rameseder J, Lee MJ, Blake EJ, Fydrych A, Ho R, Greenberger BA, Chen GC, Maffa A, Del Rosario AM, Root DE, Carpenter AE, Hahn WC, Sabatini DM, Chen CC, White FM, Bradner JE, Yaffe MB. Floyd SR, et al. Among authors: lee mj. Nature. 2013 Jun 13;498(7453):246-50. doi: 10.1038/nature12147. Epub 2013 Jun 2. Nature. 2013. PMID: 23728299 Free PMC article.
Functional genomic screens with death rate analyses reveal mechanisms of drug action.
Honeywell ME, Isidor MS, Harper NW, Fontana RE, Birdsall GA, Cruz-Gordillo P, Porto SA, Jerome M, Fraser CS, Sarosiek KA, Guertin DA, Spinelli JB, Lee MJ. Honeywell ME, et al. Among authors: lee mj. Nat Chem Biol. 2024 Nov;20(11):1443-1452. doi: 10.1038/s41589-024-01584-7. Epub 2024 Mar 13. Nat Chem Biol. 2024. PMID: 38480981
Quick tips for interpreting cell death experiments.
Dixon SJ, Lee MJ. Dixon SJ, et al. Among authors: lee mj. Nat Cell Biol. 2023 Dec;25(12):1720-1723. doi: 10.1038/s41556-023-01288-5. Nat Cell Biol. 2023. PMID: 37985871 No abstract available.
4,245 results