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Crystal structures of the naturally fused CS and cytochrome b5 reductase (b5R) domains of Ncb5or reveal an expanded CS fold, extensive CS-b5R interactions and productive binding of the NAD(P)+ nicotinamide ring.
Benson DR, Lovell S, Mehzabeen N, Galeva N, Cooper A, Gao P, Battaile KP, Zhu H. Benson DR, et al. Among authors: gao p. Acta Crystallogr D Struct Biol. 2019 Jul 1;75(Pt 7):628-638. doi: 10.1107/S205979831900754X. Epub 2019 Jun 26. Acta Crystallogr D Struct Biol. 2019. PMID: 31282472 Free PMC article.
The SARS-CoV-2 conserved macrodomain is a mono-ADP-ribosylhydrolase.
Alhammad YMO, Kashipathy MM, Roy A, Gagné JP, McDonald P, Gao P, Nonfoux L, Battaile KP, Johnson DK, Holmstrom ED, Poirier GG, Lovell S, Fehr AR. Alhammad YMO, et al. Among authors: gao p. bioRxiv [Preprint]. 2020 Oct 28:2020.05.11.089375. doi: 10.1101/2020.05.11.089375. bioRxiv. 2020. Update in: J Virol. 2021 Jan 13;95(3):e01969-20. doi: 10.1128/JVI.01969-20 PMID: 32511412 Free PMC article. Updated. Preprint.
The SARS-CoV-2 Conserved Macrodomain Is a Mono-ADP-Ribosylhydrolase.
Alhammad YMO, Kashipathy MM, Roy A, Gagné JP, McDonald P, Gao P, Nonfoux L, Battaile KP, Johnson DK, Holmstrom ED, Poirier GG, Lovell S, Fehr AR. Alhammad YMO, et al. Among authors: gao p. J Virol. 2021 Jan 13;95(3):e01969-20. doi: 10.1128/JVI.01969-20. Print 2021 Jan 13. J Virol. 2021. PMID: 33158944 Free PMC article.
HSV-1 ICP0 dimer domain adopts a novel β-barrel fold.
McCloskey E, Kashipathy M, Cooper A, Gao P, Johnson DK, Battaile KP, Lovell S, Davido DJ. McCloskey E, et al. Among authors: gao p. Proteins. 2024 Jul;92(7):830-841. doi: 10.1002/prot.26673. Epub 2024 Feb 19. Proteins. 2024. PMID: 38372168
Synthesis and biological characterization of an orally bioavailable lactate dehydrogenase-A inhibitor against pancreatic cancer.
Sharma H, Mondal S, Urquiza U, Esparza C, Bartlett S, Santa-Pinter L, Hill H, White M, Sharma P, Luckett-Chastain L, Cooper A, Rasel M, Gao P, Battaile KP, Shukla SK, Lovell S, Ihnat MA. Sharma H, et al. Among authors: gao p. Eur J Med Chem. 2024 Sep 5;275:116598. doi: 10.1016/j.ejmech.2024.116598. Epub 2024 Jun 17. Eur J Med Chem. 2024. PMID: 38925013 Free article.
Mutation of a highly conserved isoleucine residue in loop 2 of several β-coronavirus macrodomains indicates that enhanced ADP-ribose binding is detrimental for replication.
Kerr CM, Pfannenstiel JJ, Alhammad YM, O'Connor JJ, Ghimire R, Shrestha R, Khattabi R, Saenjamsai P, Parthasarathy S, McDonald PR, Gao P, Johnson DK, More S, Roy A, Channappanavar R, Fehr AR. Kerr CM, et al. Among authors: gao p. J Virol. 2024 Nov 19;98(11):e0131324. doi: 10.1128/jvi.01313-24. Epub 2024 Oct 10. J Virol. 2024. PMID: 39387584 Free article.
CYP5122A1 encodes an essential sterol C4-methyl oxidase in Leishmania donovani and determines the antileishmanial activity of antifungal azoles.
Jin Y, Basu S, Feng M, Ning Y, Munasinghe I, Joachim AM, Li J, Qin L, Madden R, Burks H, Gao P, Wu JQ, Sheikh SW, Joice AC, Perera C, Werbovetz KA, Zhang K, Wang MZ. Jin Y, et al. Among authors: gao p. Nat Commun. 2024 Oct 31;15(1):9409. doi: 10.1038/s41467-024-53790-5. Nat Commun. 2024. PMID: 39482311 Free PMC article.
7,211 results