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A further pocket or conformational plasticity by mapping COX-1 catalytic site through modified-mofezolac structure-inhibitory activity relationships and their antiplatelet behavior.
Solidoro R, Miciaccia M, Bonaccorso C, Fortuna CG, Armenise D, Centonze A, Ferorelli S, Vitale P, Rodrigues P, Guimarães R, de Oliveira A, da Paz M, Rangel L, Sathler PC, Altomare A, Perrone MG, Scilimati A. Solidoro R, et al. Eur J Med Chem. 2024 Feb 15;266:116135. doi: 10.1016/j.ejmech.2024.116135. Epub 2024 Jan 10. Eur J Med Chem. 2024. PMID: 38219659
Enzymatic synthesis of ascorbyl oleate and evaluation of biological activities.
Costa KAD, Catarina AS, Leal ICR, Sathler PC, de Oliveira D, de Oliveira AASC, Cansian RL, Dallago RM, Zeni J, Paroul N. Costa KAD, et al. Among authors: de oliveira aasc. Food Res Int. 2022 Nov;161:111851. doi: 10.1016/j.foodres.2022.111851. Epub 2022 Aug 27. Food Res Int. 2022. PMID: 36192978