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144 results

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Page 1
m6A-dependent circular RNA formation mediates tau-induced neurotoxicity.
Atrian F, Ramirez P, De Mange J, Marquez M, Gonzalez EM, Minaya M, Karch CM, Frost B. Atrian F, et al. Among authors: karch cm. bioRxiv [Preprint]. 2024 Jan 26:2024.01.25.577211. doi: 10.1101/2024.01.25.577211. bioRxiv. 2024. PMID: 38328044 Free PMC article. Preprint.
Long non-coding RNA SNHG8 drives stress granule formation in tauopathies.
Bhagat R, Minaya MA, Renganathan A, Mehra M, Marsh J, Martinez R, Nana AL, Spina S, Seeley WW, Grinberg LT, Karch CM. Bhagat R, et al. Among authors: karch cm. medRxiv [Preprint]. 2023 Mar 1:2023.02.27.23286548. doi: 10.1101/2023.02.27.23286548. medRxiv. 2023. Update in: Mol Psychiatry. 2023 Nov;28(11):4889-4901. doi: 10.1038/s41380-023-02237-2 PMID: 36909621 Free PMC article. Updated. Preprint.
Long non-coding RNA SNHG8 drives stress granule formation in tauopathies.
Bhagat R, Minaya MA, Renganathan A, Mehra M, Marsh J, Martinez R, Eteleeb AM, Nana AL, Spina S, Seeley WW, Grinberg LT, Karch CM. Bhagat R, et al. Among authors: karch cm. Mol Psychiatry. 2023 Nov;28(11):4889-4901. doi: 10.1038/s41380-023-02237-2. Epub 2023 Sep 21. Mol Psychiatry. 2023. PMID: 37730840 Free PMC article.
Mutant tau and stress lead to downregulation of long noncoding RNA, SNHG8.
Bhagat R, Minaya MA, Renganathan A, Mehra M, Marsh J, Martinez R, Eteleeb AM, Nana AL, Spina S, Seeley WW, Grinberg LT, Karch CM. Bhagat R, et al. Among authors: karch cm. Mol Psychiatry. 2023 Nov;28(11):4489. doi: 10.1038/s41380-023-02328-0. Mol Psychiatry. 2023. PMID: 38443679 Free PMC article. No abstract available.
Cell autonomous microglia defects in a stem cell model of frontotemporal dementia.
Iyer AK, Vermunt L, Mirfakhar FS, Minaya M, Acquarone M, Koppisetti RK, Renganathan A, You SF, Danhash EP, Verbeck A, Galasso G, Lee SM, Marsh J, Nana AL, Spina S, Seeley WW, Grinberg LT, Temple S, Teunissen CE, Sato C, Karch CM. Iyer AK, et al. Among authors: karch cm. medRxiv [Preprint]. 2024 May 16:2024.05.15.24307444. doi: 10.1101/2024.05.15.24307444. medRxiv. 2024. PMID: 38798451 Free PMC article. Preprint.
Current directions in tau research: Highlights from Tau 2020.
Sexton C, Snyder H, Beher D, Boxer AL, Brannelly P, Brion JP, Buée L, Cacace AM, Chételat G, Citron M, DeVos SL, Diaz K, Feldman HH, Frost B, Goate AM, Gold M, Hyman B, Johnson K, Karch CM, Kerwin DR, Koroshetz WJ, Litvan I, Morris HR, Mummery CJ, Mutamba J, Patterson MC, Quiroz YT, Rabinovici GD, Rommel A, Shulman MB, Toledo-Sherman LM, Weninger S, Wildsmith KR, Worley SL, Carrillo MC. Sexton C, et al. Among authors: karch cm. Alzheimers Dement. 2022 May;18(5):988-1007. doi: 10.1002/alz.12452. Epub 2021 Sep 28. Alzheimers Dement. 2022. PMID: 34581500 Review.
Defects in lysosomal function and lipid metabolism in human microglia harboring a TREM2 loss of function mutation.
Filipello F, You SF, Mirfakhar FS, Mahali S, Bollman B, Acquarone M, Korvatska O, Marsh JA, Sivaraman A, Martinez R, Cantoni C, De Feo L, Ghezzi L, Minaya MA, Renganathan A, Cashikar AG, Satoh JI, Beatty W, Iyer AK, Cella M, Raskind WH, Piccio L, Karch CM. Filipello F, et al. Among authors: karch cm. Acta Neuropathol. 2023 Jun;145(6):749-772. doi: 10.1007/s00401-023-02568-y. Epub 2023 Apr 28. Acta Neuropathol. 2023. PMID: 37115208 Free PMC article.
Novel avenues of tau research.
Sexton CE, Bitan G, Bowles KR, Brys M, Buée L, Maina MB, Clelland CD, Cohen AD, Crary JF, Dage JL, Diaz K, Frost B, Gan L, Goate AM, Golbe LI, Hansson O, Karch CM, Kolb HC, La Joie R, Lee SE, Matallana D, Miller BL, Onyike CU, Quiroz YT, Rexach JE, Rohrer JD, Rommel A, Sadri-Vakili G, Schindler SE, Schneider JA, Sperling RA, Teunissen CE, Weninger SC, Worley SL, Zheng H, Carrillo MC. Sexton CE, et al. Among authors: karch cm. Alzheimers Dement. 2024 Mar;20(3):2240-2261. doi: 10.1002/alz.13533. Epub 2024 Jan 3. Alzheimers Dement. 2024. PMID: 38170841 Free PMC article. Review.
Endogenous recapitulation of Alzheimer's disease neuropathology through human 3D direct neuronal reprogramming.
Sun Z, Kwon JS, Ren Y, Chen S, Cates K, Lu X, Walker CK, Karahan H, Sviben S, Fitzpatrick JAJ, Valdez C, Houlden H, Karch CM, Bateman RJ, Sato C, Mennerick SJ, Diamond MI, Kim J, Tanzi RE, Holtzman DM, Yoo AS. Sun Z, et al. Among authors: karch cm. bioRxiv [Preprint]. 2023 May 25:2023.05.24.542155. doi: 10.1101/2023.05.24.542155. bioRxiv. 2023. Update in: Science. 2024 Aug 2;385(6708):adl2992. doi: 10.1126/science.adl2992 PMID: 37292658 Free PMC article. Updated. Preprint.
Comparison of tau spread in people with Down syndrome versus autosomal-dominant Alzheimer's disease: a cross-sectional study.
Wisch JK, McKay NS, Boerwinkle AH, Kennedy J, Flores S, Handen BL, Christian BT, Head E, Mapstone M, Rafii MS, O'Bryant SE, Price JC, Laymon CM, Krinsky-McHale SJ, Lai F, Rosas HD, Hartley SL, Zaman S, Lott IT, Tudorascu D, Zammit M, Brickman AM, Lee JH, Bird TD, Cohen A, Chrem P, Daniels A, Chhatwal JP, Cruchaga C, Ibanez L, Jucker M, Karch CM, Day GS, Lee JH, Levin J, Llibre-Guerra J, Li Y, Lopera F, Roh JH, Ringman JM, Supnet-Bell C, van Dyck CH, Xiong C, Wang G, Morris JC, McDade E, Bateman RJ, Benzinger TLS, Gordon BA, Ances BM; Alzheimer's Biomarker Consortium-Down syndrome; Dominantly Inherited Alzheimer Network. Wisch JK, et al. Among authors: karch cm. Lancet Neurol. 2024 May;23(5):500-510. doi: 10.1016/S1474-4422(24)00084-X. Lancet Neurol. 2024. PMID: 38631766
144 results