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O-GlcNAc forces an α-synuclein amyloid strain with notably diminished seeding and pathology.
Balana AT, Mahul-Mellier AL, Nguyen BA, Horvath M, Javed A, Hard ER, Jasiqi Y, Singh P, Afrin S, Pedretti R, Singh V, Lee VM, Luk KC, Saelices L, Lashuel HA, Pratt MR. Balana AT, et al. Among authors: lashuel ha. Nat Chem Biol. 2024 May;20(5):646-655. doi: 10.1038/s41589-024-01551-2. Epub 2024 Feb 12. Nat Chem Biol. 2024. PMID: 38347213 Free PMC article.
c-Abl phosphorylates α-synuclein and regulates its degradation: implication for α-synuclein clearance and contribution to the pathogenesis of Parkinson's disease.
Mahul-Mellier AL, Fauvet B, Gysbers A, Dikiy I, Oueslati A, Georgeon S, Lamontanara AJ, Bisquertt A, Eliezer D, Masliah E, Halliday G, Hantschel O, Lashuel HA. Mahul-Mellier AL, et al. Among authors: lashuel ha. Hum Mol Genet. 2014 Jun 1;23(11):2858-79. doi: 10.1093/hmg/ddt674. Epub 2014 Jan 9. Hum Mol Genet. 2014. PMID: 24412932 Free PMC article.
The H50Q mutation enhances α-synuclein aggregation, secretion, and toxicity.
Khalaf O, Fauvet B, Oueslati A, Dikiy I, Mahul-Mellier AL, Ruggeri FS, Mbefo MK, Vercruysse F, Dietler G, Lee SJ, Eliezer D, Lashuel HA. Khalaf O, et al. Among authors: lashuel ha. J Biol Chem. 2014 Aug 8;289(32):21856-76. doi: 10.1074/jbc.M114.553297. Epub 2014 Jun 16. J Biol Chem. 2014. PMID: 24936070 Free PMC article.
Semisynthetic and in Vitro Phosphorylation of Alpha-Synuclein at Y39 Promotes Functional Partly Helical Membrane-Bound States Resembling Those Induced by PD Mutations.
Dikiy I, Fauvet B, Jovičić A, Mahul-Mellier AL, Desobry C, El-Turk F, Gitler AD, Lashuel HA, Eliezer D. Dikiy I, et al. Among authors: lashuel ha. ACS Chem Biol. 2016 Sep 16;11(9):2428-37. doi: 10.1021/acschembio.6b00539. Epub 2016 Jul 11. ACS Chem Biol. 2016. PMID: 27356045 Free PMC article.
Amyloid single-cell cytotoxicity assays by nanomotion detection.
Ruggeri FS, Mahul-Mellier AL, Kasas S, Lashuel HA, Longo G, Dietler G. Ruggeri FS, et al. Among authors: lashuel ha. Cell Death Discov. 2017 Aug 21;3:17053. doi: 10.1038/cddiscovery.2017.53. eCollection 2017. Cell Death Discov. 2017. PMID: 28845298 Free PMC article.
The process of Lewy body formation, rather than simply α-synuclein fibrillization, is one of the major drivers of neurodegeneration.
Mahul-Mellier AL, Burtscher J, Maharjan N, Weerens L, Croisier M, Kuttler F, Leleu M, Knott GW, Lashuel HA. Mahul-Mellier AL, et al. Among authors: lashuel ha. Proc Natl Acad Sci U S A. 2020 Mar 3;117(9):4971-4982. doi: 10.1073/pnas.1913904117. Epub 2020 Feb 19. Proc Natl Acad Sci U S A. 2020. PMID: 32075919 Free PMC article.
212 results