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Single-molecule chromatin configurations link transcription factor binding to expression in human cells.
Doughty BR, Hinks MM, Schaepe JM, Marinov GK, Thurm AR, Rios-Martinez C, Parks BE, Tan Y, Marklund E, Dubocanin D, Bintu L, Greenleaf WJ. Doughty BR, et al. Among authors: marklund e. bioRxiv [Preprint]. 2024 Feb 4:2024.02.02.578660. doi: 10.1101/2024.02.02.578660. bioRxiv. 2024. Update in: Nature. 2024 Dec;636(8043):745-754. doi: 10.1038/s41586-024-08219-w PMID: 38352517 Free PMC article. Updated. Preprint.
DNA surface exploration and operator bypassing during target search.
Marklund E, van Oosten B, Mao G, Amselem E, Kipper K, Sabantsev A, Emmerich A, Globisch D, Zheng X, Lehmann LC, Berg OG, Johansson M, Elf J, Deindl S. Marklund E, et al. Nature. 2020 Jul;583(7818):858-861. doi: 10.1038/s41586-020-2413-7. Epub 2020 Jun 24. Nature. 2020. PMID: 32581356
Mechanistic Insights into Autoinhibition of the Oncogenic Chromatin Remodeler ALC1.
Lehmann LC, Hewitt G, Aibara S, Leitner A, Marklund E, Maslen SL, Maturi V, Chen Y, van der Spoel D, Skehel JM, Moustakas A, Boulton SJ, Deindl S. Lehmann LC, et al. Among authors: marklund e. Mol Cell. 2017 Dec 7;68(5):847-859.e7. doi: 10.1016/j.molcel.2017.10.017. Mol Cell. 2017. PMID: 29220652 Free PMC article.
Short tandem repeats bind transcription factors to tune eukaryotic gene expression.
Horton CA, Alexandari AM, Hayes MGB, Marklund E, Schaepe JM, Aditham AK, Shah N, Suzuki PH, Shrikumar A, Afek A, Greenleaf WJ, Gordân R, Zeitlinger J, Kundaje A, Fordyce PM. Horton CA, et al. Among authors: marklund e. Science. 2023 Sep 22;381(6664):eadd1250. doi: 10.1126/science.add1250. Epub 2023 Sep 22. Science. 2023. PMID: 37733848
Single-molecule states link transcription factor binding to gene expression.
Doughty BR, Hinks MM, Schaepe JM, Marinov GK, Thurm AR, Rios-Martinez C, Parks BE, Tan Y, Marklund E, Dubocanin D, Bintu L, Greenleaf WJ. Doughty BR, et al. Among authors: marklund e. Nature. 2024 Dec;636(8043):745-754. doi: 10.1038/s41586-024-08219-w. Epub 2024 Nov 20. Nature. 2024. PMID: 39567683
85 results