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Page 1
Alkylamine-tethered molecules recruit FBXO22 for targeted protein degradation.
Kagiou C, Cisneros JA, Farnung J, Liwocha J, Offensperger F, Dong K, Yang K, Tin G, Horstmann CS, Hinterndorfer M, Paulo JA, Scholes NS, Sanchez Avila J, Fellner M, Andersch F, Hannich JT, Zuber J, Kubicek S, Gygi SP, Schulman BA, Winter GE. Kagiou C, et al. Among authors: liwocha j. Nat Commun. 2024 Jun 26;15(1):5409. doi: 10.1038/s41467-024-49739-3. Nat Commun. 2024. PMID: 38926334 Free PMC article.
Cullin-RING ligases employ geometrically optimized catalytic partners for substrate targeting.
Li J, Purser N, Liwocha J, Scott DC, Byers HA, Steigenberger B, Hill S, Tripathi-Giesgen I, Hinkle T, Hansen FM, Prabu JR, Radhakrishnan SK, Kirkpatrick DS, Reichermeier KM, Schulman BA, Kleiger G. Li J, et al. Among authors: liwocha j. Mol Cell. 2024 Apr 4;84(7):1304-1320.e16. doi: 10.1016/j.molcel.2024.01.022. Epub 2024 Feb 20. Mol Cell. 2024. PMID: 38382526 Free PMC article.
Hydrostatic Pressure Sensing by WNK kinases.
Humphreys JM, Teixeira LR, Akella R, He H, Kannangara AR, Sekulski K, Pleinis J, Liwocha J, Jiou J, Servage KA, Orth K, Joachimiak L, Rizo J, Cobb MH, Brautigam CA, Rodan AR, Goldsmith EJ. Humphreys JM, et al. Among authors: liwocha j. Mol Biol Cell. 2023 Oct 1;34(11):ar109. doi: 10.1091/mbc.E23-03-0113. Epub 2023 Aug 16. Mol Biol Cell. 2023. PMID: 37585288 Free PMC article.
Osmosensing by WNK Kinases.
Akella R, Humphreys JM, Sekulski K, He H, Durbacz M, Chakravarthy S, Liwocha J, Mohammed ZJ, Brautigam CA, Goldsmith EJ. Akella R, et al. Among authors: liwocha j. Mol Biol Cell. 2021 Aug 19;32(18):1614-1623. doi: 10.1091/mbc.E20-01-0089. Epub 2021 Mar 10. Mol Biol Cell. 2021. PMID: 33689398 Free PMC article.
Linkage-specific ubiquitin chain formation depends on a lysine hydrocarbon ruler.
Liwocha J, Krist DT, van der Heden van Noort GJ, Hansen FM, Truong VH, Karayel O, Purser N, Houston D, Burton N, Bostock MJ, Sattler M, Mann M, Harrison JS, Kleiger G, Ovaa H, Schulman BA. Liwocha J, et al. Nat Chem Biol. 2021 Mar;17(3):272-279. doi: 10.1038/s41589-020-00696-0. Epub 2020 Dec 7. Nat Chem Biol. 2021. PMID: 33288957 Free PMC article.
A Phosphorylated Intermediate in the Activation of WNK Kinases.
Akella R, Drozdz MA, Humphreys JM, Jiou J, Durbacz MZ, Mohammed ZJ, He H, Liwocha J, Sekulski K, Goldsmith EJ. Akella R, et al. Among authors: liwocha j. Biochemistry. 2020 May 12;59(18):1747-1755. doi: 10.1021/acs.biochem.0c00146. Epub 2020 Apr 24. Biochemistry. 2020. PMID: 32314908 Free PMC article.