Coombes BK - Search Results

1

A Nanocomposite Dynamic Covalent Cross-Linked Hydrogel Loaded with Fusidic Acid for Treating Antibiotic-Resistant Infected Wounds.

Toufanian S, Mohammed J, Winterhelt E, Lofts A, Dave R, Coombes BK, Hoare T. Toufanian S, et al. Among authors: coombes bk. ACS Appl Bio Mater. 2024 Mar 18;7(3):1947-1957. doi: 10.1021/acsabm.3c01293. Epub 2024 Feb 23. ACS Appl Bio Mater. 2024. PMID: 38394042

2

Deep learning-guided discovery of an antibiotic targeting Acinetobacter baumannii.

Liu G, Catacutan DB, Rathod K, Swanson K, Jin W, Mohammed JC, Chiappino-Pepe A, Syed SA, Fragis M, Rachwalski K, Magolan J, Surette MG, Coombes BK, Jaakkola T, Barzilay R, Collins JJ, Stokes JM. Liu G, et al. Among authors: coombes bk. Nat Chem Biol. 2023 Nov;19(11):1342-1350. doi: 10.1038/s41589-023-01349-8. Epub 2023 May 25. Nat Chem Biol. 2023. PMID: 37231267

3

Zinc Chelation by a Small-Molecule Adjuvant Potentiates Meropenem Activity in Vivo against NDM-1-Producing Klebsiella pneumoniae.

Falconer SB, Reid-Yu SA, King AM, Gehrke SS, Wang W, Britten JF, Coombes BK, Wright GD, Brown ED. Falconer SB, et al. Among authors: coombes bk. ACS Infect Dis. 2015 Nov 13;1(11):533-43. doi: 10.1021/acsinfecdis.5b00033. Epub 2015 May 26. ACS Infect Dis. 2015. PMID: 27623408

4

Screening under infection-relevant conditions reveals chemical sensitivity in multidrug resistant invasive non-typhoidal Salmonella (iNTS).

Tsai CN, Massicotte MA, MacNair CR, Perry JN, Brown ED, Coombes BK. Tsai CN, et al. Among authors: coombes bk. RSC Chem Biol. 2023 Jul 8;4(8):600-612. doi: 10.1039/d3cb00014a. eCollection 2023 Aug 3. RSC Chem Biol. 2023. PMID: 37547457 Free PMC article.

5

Genetic and Chemical Screening Reveals Targets and Compounds to Potentiate Gram-Positive Antibiotics against Gram-Negative Bacteria.

Klobucar K, Jardine E, Farha MA, MacKinnon MR, Fragis M, Nkonge B, Bhando T, Borrillo L, Tsai CN, Johnson JW, Coombes BK, Magolan J, Brown ED. Klobucar K, et al. Among authors: coombes bk. ACS Infect Dis. 2022 Oct 14;8(10):2187-2197. doi: 10.1021/acsinfecdis.2c00357. Epub 2022 Sep 13. ACS Infect Dis. 2022. PMID: 36098580

6

Synthetic Biology Facilitates Semisynthetic Development of Type V Glycopeptide Antibiotics Targeting Vancomycin-Resistant Enterococcus.

Koteva K, Xu M, Wang W, Fiebig-Comyn AA, Cook MA, Coombes BK, Wright GD. Koteva K, et al. Among authors: coombes bk. J Med Chem. 2023 Jul 13;66(13):9006-9022. doi: 10.1021/acs.jmedchem.3c00633. Epub 2023 Jun 14. J Med Chem. 2023. PMID: 37315221 Free PMC article.

7

Genetic and Chemical Screening in Human Blood Serum Reveals Unique Antibacterial Targets and Compounds against Klebsiella pneumoniae.

Weber BS, De Jong AM, Guo ABY, Dharavath S, French S, Fiebig-Comyn AA, Coombes BK, Magolan J, Brown ED. Weber BS, et al. Among authors: coombes bk. Cell Rep. 2020 Jul 21;32(3):107927. doi: 10.1016/j.celrep.2020.107927. Cell Rep. 2020. PMID: 32698013 Free article.

8

Overcoming mcr-1 mediated colistin resistance with colistin in combination with other antibiotics.

MacNair CR, Stokes JM, Carfrae LA, Fiebig-Comyn AA, Coombes BK, Mulvey MR, Brown ED. MacNair CR, et al. Among authors: coombes bk. Nat Commun. 2018 Jan 31;9(1):458. doi: 10.1038/s41467-018-02875-z. Nat Commun. 2018. PMID: 29386620 Free PMC article.

9

Evolution-guided discovery of antibiotics that inhibit peptidoglycan remodelling.

Culp EJ, Waglechner N, Wang W, Fiebig-Comyn AA, Hsu YP, Koteva K, Sychantha D, Coombes BK, Van Nieuwenhze MS, Brun YV, Wright GD. Culp EJ, et al. Among authors: coombes bk. Nature. 2020 Feb;578(7796):582-587. doi: 10.1038/s41586-020-1990-9. Epub 2020 Feb 12. Nature. 2020. PMID: 32051588

10

Combinations of antibiotics and nonantibiotic drugs enhance antimicrobial efficacy.

Ejim L, Farha MA, Falconer SB, Wildenhain J, Coombes BK, Tyers M, Brown ED, Wright GD. Ejim L, et al. Among authors: coombes bk. Nat Chem Biol. 2011 Jun;7(6):348-50. doi: 10.1038/nchembio.559. Epub 2011 Apr 24. Nat Chem Biol. 2011. PMID: 21516114

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