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Discovery of CS-2100, a potent, orally active and S1P3-sparing S1P1 agonist.
Nakamura T, Asano M, Sekiguchi Y, Mizuno Y, Tamaki K, Kimura T, Nara F, Kawase Y, Shimozato T, Doi H, Kagari T, Tomisato W, Inoue R, Nagasaki M, Yuita H, Oguchi-Oshima K, Kaneko R, Watanabe N, Abe Y, Nishi T. Nakamura T, et al. Among authors: kawase y. Bioorg Med Chem Lett. 2012 Feb 15;22(4):1788-92. doi: 10.1016/j.bmcl.2011.12.019. Epub 2012 Jan 2. Bioorg Med Chem Lett. 2012. PMID: 22264485
Synthesis and evaluation of CS-2100, a potent, orally active and S1P(3)- sparing S1P(1) agonist.
Nakamura T, Asano M, Sekiguchi Y, Mizuno Y, Tamaki K, Nara F, Kawase Y, Yabe Y, Nakai D, Kamiyama E, Urasaki-Kaneno Y, Shimozato T, Doi-Komuro H, Kagari T, Tomisato W, Inoue R, Nagasaki M, Yuita H, Oguchi-Oshima K, Kaneko R, Nishi T. Nakamura T, et al. Among authors: kawase y. Eur J Med Chem. 2012 May;51:92-8. doi: 10.1016/j.ejmech.2012.02.022. Epub 2012 Feb 25. Eur J Med Chem. 2012. PMID: 22405291
Blockade of SIRPα-CD47 axis by anti-SIRPα antibody enhances anti-tumor activity of DXd antibody-drug conjugates.
Sue M, Tsubaki T, Ishimoto Y, Hayashi S, Ishida S, Otsuka T, Isumi Y, Kawase Y, Yamaguchi J, Nakada T, Ishiguro J, Nakamura K, Kawaida R, Ohtsuka T, Wada T, Agatsuma T, Kawasaki N. Sue M, et al. Among authors: kawase y. PLoS One. 2024 Jun 6;19(6):e0304985. doi: 10.1371/journal.pone.0304985. eCollection 2024. PLoS One. 2024. PMID: 38843278 Free PMC article.
Synthesis and SAR of 1,3-thiazolyl thiophene and pyridine derivatives as potent, orally active and S1P₃-sparing S1P₁ agonists.
Asano M, Nakamura T, Sekiguchi Y, Mizuno Y, Yamaguchi T, Tamaki K, Shimozato T, Doi-Komuro H, Kagari T, Tomisato W, Inoue R, Yuita H, Oguchi-Oshima K, Kaneko R, Nara F, Kawase Y, Masubuchi N, Nakayama S, Koga T, Namba E, Nasu H, Nishi T. Asano M, et al. Among authors: kawase y. Bioorg Med Chem Lett. 2012 May 1;22(9):3083-8. doi: 10.1016/j.bmcl.2012.03.067. Epub 2012 Mar 23. Bioorg Med Chem Lett. 2012. PMID: 22487179
A novel [5.2.1]bicyclic amine is a potent analgesic without µ opioid activity.
Noguchi T, Umezaki Y, Takano R, Fujimoto T, Domon Y, Kubota K, Ueda K, Kawase Y, Yabe K, Yokoyama M, Shimada K. Noguchi T, et al. Among authors: kawase y. Bioorg Med Chem Lett. 2021 Mar 15;36:127790. doi: 10.1016/j.bmcl.2021.127790. Epub 2021 Jan 14. Bioorg Med Chem Lett. 2021. PMID: 33454387
Discovery of CS-0777: A Potent, Selective, and Orally Active S1P1 Agonist.
Nishi T, Miyazaki S, Takemoto T, Suzuki K, Iio Y, Nakajima K, Ohnuki T, Kawase Y, Nara F, Inaba S, Izumi T, Yuita H, Oshima K, Doi H, Inoue R, Tomisato W, Kagari T, Shimozato T. Nishi T, et al. Among authors: kawase y. ACS Med Chem Lett. 2011 Mar 2;2(5):368-72. doi: 10.1021/ml100301k. eCollection 2011 May 12. ACS Med Chem Lett. 2011. PMID: 24900318 Free PMC article.
680 results