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Patients with multiple sclerosis who develop immunogenicity to interferon-beta have distinct transcriptomic and proteomic signatures prior to treatment which are associated with disease severity.
Coelewij L, Adriani M, Dönnes P, Waddington KE, Ciurtin C, Havrdova EK; ABIRISK Consortium; Farrell R, Nytrova P, Pineda-Torra I, Jury EC. Coelewij L, et al. Clin Immunol. 2024 Oct;267:110339. doi: 10.1016/j.clim.2024.110339. Epub 2024 Aug 11. Clin Immunol. 2024. PMID: 39137826 Free article.
Impact of immunogenicity on clinical efficacy and toxicity profile of biologic agents used for treatment of inflammatory arthritis in children compared to adults.
Parikh CR, Ponnampalam JK, Seligmann G, Coelewij L, Pineda-Torra I, Jury EC, Ciurtin C. Parikh CR, et al. Among authors: coelewij l. Ther Adv Musculoskelet Dis. 2021 Jun 16;13:1759720X211002685. doi: 10.1177/1759720X211002685. eCollection 2021. Ther Adv Musculoskelet Dis. 2021. PMID: 34188697 Free PMC article. Review.
Serum Metabolomic Signatures Can Predict Subclinical Atherosclerosis in Patients With Systemic Lupus Erythematosus.
Coelewij L, Waddington KE, Robinson GA, Chocano E, McDonnell T, Farinha F, Peng J, Dönnes P, Smith E, Croca S, Bakshi J, Griffin M, Nicolaides A, Rahman A, Jury EC, Pineda-Torra I. Coelewij L, et al. Arterioscler Thromb Vasc Biol. 2021 Apr;41(4):1446-1458. doi: 10.1161/ATVBAHA.120.315321. Epub 2021 Feb 4. Arterioscler Thromb Vasc Biol. 2021. PMID: 33535791 Free PMC article.
Disease-associated and patient-specific immune cell signatures in juvenile-onset systemic lupus erythematosus: patient stratification using a machine-learning approach.
Robinson GA, Peng J, Dönnes P, Coelewij L, Naja M, Radziszewska A, Wincup C, Peckham H, Isenberg DA, Ioannou Y, Pineda-Torra I, Ciurtin C, Jury EC. Robinson GA, et al. Among authors: coelewij l. Lancet Rheumatol. 2020 Jul 29;2(8):e485-e496. doi: 10.1016/S2665-9913(20)30168-5. eCollection 2020 Aug. Lancet Rheumatol. 2020. PMID: 32818204 Free PMC article.