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Hepatic malonyl-CoA synthesis restrains gluconeogenesis by suppressing fat oxidation, pyruvate carboxylation, and amino acid availability.
Deja S, Fletcher JA, Kim CW, Kucejova B, Fu X, Mizerska M, Villegas M, Pudelko-Malik N, Browder N, Inigo-Vollmer M, Menezes CJ, Mishra P, Berglund ED, Browning JD, Thyfault JP, Young JD, Horton JD, Burgess SC. Deja S, et al. Among authors: thyfault jp. Cell Metab. 2024 May 7;36(5):1088-1104.e12. doi: 10.1016/j.cmet.2024.02.004. Epub 2024 Mar 5. Cell Metab. 2024. PMID: 38447582 Free article.
Disruption of hepatic mitochondrial pyruvate and amino acid metabolism impairs gluconeogenesis and endurance exercise capacity in mice.
Martino MR, Habibi M, Ferguson D, Brookheart RT, Thyfault JP, Meyer GA, Lantier L, Hughey CC, Finck BN. Martino MR, et al. Among authors: thyfault jp. Am J Physiol Endocrinol Metab. 2024 Apr 1;326(4):E515-E527. doi: 10.1152/ajpendo.00258.2023. Epub 2024 Feb 14. Am J Physiol Endocrinol Metab. 2024. PMID: 38353639 Free PMC article.
Disruption of Hepatic Mitochondrial Pyruvate and Amino Acid Metabolism Impairs Gluconeogenesis and Endurance Exercise Capacity in Mice.
Martino MR, Habibi M, Ferguson D, Brookheart RT, Thyfault JP, Meyer GA, Lantier L, Hughey CC, Finck BN. Martino MR, et al. Among authors: thyfault jp. bioRxiv [Preprint]. 2023 Aug 23:2023.08.22.554345. doi: 10.1101/2023.08.22.554345. bioRxiv. 2023. Update in: Am J Physiol Endocrinol Metab. 2024 Apr 1;326(4):E515-E527. doi: 10.1152/ajpendo.00258.2023 PMID: 37662392 Free PMC article. Updated. Preprint.
VCD-induced menopause mouse model reveals reprogramming of hepatic metabolism.
Kumari R, Ponte ME, Franczak E, Prom JC, O'Neil MF, Sardiu ME, Lutkewitte AJ, Christenson LK, Shankar K, Morris EM, Thyfault JP. Kumari R, et al. Among authors: thyfault jp. Mol Metab. 2024 Apr;82:101908. doi: 10.1016/j.molmet.2024.101908. Epub 2024 Mar 1. Mol Metab. 2024. PMID: 38432400 Free PMC article.
Intrinsic aerobic capacity modulates Alzheimer's disease pathological hallmarks, brain mitochondrial function and proteome during aging.
Kugler BA, Lysaker CR, Franczak E, Hauger BM, Csikos V, Stopperan JA, Allen JA, Stanford JA, Koch LG, Britton SL, Thyfault JP, Wilkins HM. Kugler BA, et al. Among authors: thyfault jp. Geroscience. 2024 Oct;46(5):4955-4967. doi: 10.1007/s11357-024-01248-3. Epub 2024 Jun 13. Geroscience. 2024. PMID: 38867031 Free PMC article.
Ketolysis is Required for the Proper Development and Function of the Somatosensory Nervous System.
Enders J, Jack J, Thomas S, Lynch P, Lasnier S, Cao X, Swanson MT, Ryals JM, Thyfault JP, Puchalska P, Crawford PA, Wright DE. Enders J, et al. Among authors: thyfault jp. bioRxiv [Preprint]. 2023 Mar 30:2023.01.11.523492. doi: 10.1101/2023.01.11.523492. bioRxiv. 2023. Update in: Exp Neurol. 2023 Jul;365:114428. doi: 10.1016/j.expneurol.2023.114428 PMID: 36711538 Free PMC article. Updated. Preprint.
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[No authors listed] [No authors listed] PMID: 39750938
201 results