Jenkins LM - Search Results

1

The Novel ATR Inhibitor M1774 Induces Replication Protein Overexpression and Broad Synergy with DNA-targeted Anticancer Drugs.

Jo U, Arakawa Y, Zimmermann A, Taniyama D, Mizunuma M, Jenkins LM, Maity T, Kumar S, Zenke FT, Takebe N, Pommier Y. Jo U, et al. Among authors: jenkins lm. Mol Cancer Ther. 2024 Jul 2;23(7):911-923. doi: 10.1158/1535-7163.MCT-23-0402. Mol Cancer Ther. 2024. PMID: 38466804 Free PMC article.

2

SLFN11 Inactivation Induces Proteotoxic Stress and Sensitizes Cancer Cells to Ubiquitin Activating Enzyme Inhibitor TAK-243.

Murai Y, Jo U, Murai J, Jenkins LM, Huang SN, Chakka S, Chen L, Cheng K, Fukuda S, Takebe N, Pommier Y. Murai Y, et al. Among authors: jenkins lm. Cancer Res. 2021 Jun 1;81(11):3067-3078. doi: 10.1158/0008-5472.CAN-20-2694. Epub 2021 Apr 16. Cancer Res. 2021. PMID: 33863777 Free PMC article.

3

PARylation prevents the proteasomal degradation of topoisomerase I DNA-protein crosslinks and induces their deubiquitylation.

Sun Y, Chen J, Huang SN, Su YP, Wang W, Agama K, Saha S, Jenkins LM, Pascal JM, Pommier Y. Sun Y, et al. Among authors: jenkins lm. Nat Commun. 2021 Aug 18;12(1):5010. doi: 10.1038/s41467-021-25252-9. Nat Commun. 2021. PMID: 34408146 Free PMC article.

4

Resolution of R-loops by topoisomerase III-β (TOP3B) in coordination with the DEAD-box helicase DDX5.

Saha S, Yang X, Huang SN, Agama K, Baechler SA, Sun Y, Zhang H, Saha LK, Su S, Jenkins LM, Wang W, Pommier Y. Saha S, et al. Among authors: jenkins lm. Cell Rep. 2022 Jul 12;40(2):111067. doi: 10.1016/j.celrep.2022.111067. Cell Rep. 2022. PMID: 35830799 Free PMC article.

5

The small molecule inhibitor NAV-2729 has a complex target profile including multiple ADP-ribosylation factor regulatory proteins.

Rosenberg EM Jr, Jian X, Soubias O, Yoon HY, Yadav MP, Hammoudeh S, Pallikkuth S, Akpan I, Chen PW, Maity TK, Jenkins LM, Yohe ME, Byrd RA, Randazzo PA. Rosenberg EM Jr, et al. Among authors: jenkins lm. J Biol Chem. 2023 Mar;299(3):102992. doi: 10.1016/j.jbc.2023.102992. Epub 2023 Feb 8. J Biol Chem. 2023. PMID: 36758799 Free PMC article.

6

J-domain Proteins form Binary Complexes with Hsp90 and Ternary Complexes with Hsp90 and Hsp70.

Wickramaratne AC, Liao JY, Doyle SM, Hoskins JR, Puller G, Scott ML, Alao JP, Obaseki I, Dinan JC, Maity TK, Jenkins LM, Kravats AN, Wickner S. Wickramaratne AC, et al. Among authors: jenkins lm. J Mol Biol. 2023 Sep 1;435(17):168184. doi: 10.1016/j.jmb.2023.168184. Epub 2023 Jun 20. J Mol Biol. 2023. PMID: 37348754 Free PMC article.

7

The TDRD3-USP9X complex and MIB1 regulate TOP3B homeostasis and prevent deleterious TOP3B cleavage complexes.

Saha S, Huang SN, Yang X, Saha LK, Sun Y, Khandagale P, Jenkins LM, Pommier Y. Saha S, et al. Among authors: jenkins lm. Nat Commun. 2023 Nov 18;14(1):7524. doi: 10.1038/s41467-023-43151-z. Nat Commun. 2023. PMID: 37980342 Free PMC article.

8

YAP localization mediates mechanical adaptation of human cancer cells during extravasation in vivo.

So WY, Wong CS, Azubuike UF, Paul CD, Sangsari PR, Gordon PB, Gong H, Maity TK, Lim P, Yang Z, Haryanto CA, Batchelor E, Jenkins LM, Morgan NY, Tanner K. So WY, et al. Among authors: jenkins lm. bioRxiv [Preprint]. 2023 Nov 16:2023.11.14.567015. doi: 10.1101/2023.11.14.567015. bioRxiv. 2023. PMID: 38076880 Free PMC article. Preprint.

9

The Methyltransferases METTL7A and METTL7B Confer Resistance to Thiol-Based Histone Deacetylase Inhibitors.

Robey RW, Fitzsimmons CM, Guiblet WM, Frye WJE, González Dalmasy JM, Wang L, Russell DA, Huff LM, Perciaccante AJ, Ali-Rahmani F, Lipsey CC, Wade HM, Mitchell AV, Maligireddy SS, Terrero D, Butcher D, Edmondson EF, Jenkins LM, Nikitina T, Zhurkin VB, Tiwari AK, Piscopio AD, Totah RA, Bates SE, Arda HE, Gottesman MM, Batista PJ. Robey RW, et al. Among authors: jenkins lm. Mol Cancer Ther. 2024 Apr 2;23(4):464-477. doi: 10.1158/1535-7163.MCT-23-0144. Mol Cancer Ther. 2024. PMID: 38151817 Free PMC article.

10

Staufen1 Represses the FOXA1-Regulated Transcriptome by Destabilizing FOXA1 mRNA in Colorectal Cancer Cells.

Pasterczyk KR, Li XL, Singh R, Zibitt MS, Hartford CCR, Pongor L, Jenkins LM, Hu Y, Zhao PX, Muys BR, Kumar S, Roper N, Aladjem MI, Pommier Y, Grammatikakis I, Lal A. Pasterczyk KR, et al. Among authors: jenkins lm. Mol Cell Biol. 2024;44(2):43-56. doi: 10.1080/10985549.2024.2307574. Epub 2024 Feb 12. Mol Cell Biol. 2024. PMID: 38347726

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