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Antibody-independent protection against heterologous SARS-CoV-2 challenge conferred by prior infection or vaccination.
Fumagalli V, Ravà M, Marotta D, Di Lucia P, Bono EB, Giustini L, De Leo F, Casalgrandi M, Monteleone E, Mouro V, Malpighi C, Perucchini C, Grillo M, De Palma S, Donnici L, Marchese S, Conti M, Muramatsu H, Perlman S, Pardi N, Kuka M, De Francesco R, Bianchi ME, Guidotti LG, Iannacone M. Fumagalli V, et al. Among authors: bianchi me. Nat Immunol. 2024 Apr;25(4):633-643. doi: 10.1038/s41590-024-01787-z. Epub 2024 Mar 14. Nat Immunol. 2024. PMID: 38486021 Free PMC article.
HMGB1 as biomarker and drug target.
Venereau E, De Leo F, Mezzapelle R, Careccia G, Musco G, Bianchi ME. Venereau E, et al. Among authors: bianchi me. Pharmacol Res. 2016 Sep;111:534-544. doi: 10.1016/j.phrs.2016.06.031. Epub 2016 Jul 1. Pharmacol Res. 2016. PMID: 27378565 Review.
Diflunisal targets the HMGB1/CXCL12 heterocomplex and blocks immune cell recruitment.
De Leo F, Quilici G, Tirone M, De Marchis F, Mannella V, Zucchelli C, Preti A, Gori A, Casalgrandi M, Mezzapelle R, Bianchi ME, Musco G. De Leo F, et al. Among authors: bianchi me. EMBO Rep. 2019 Oct 4;20(10):e47788. doi: 10.15252/embr.201947788. Epub 2019 Aug 14. EMBO Rep. 2019. PMID: 31418171 Free PMC article.
Nucleosomes effectively shield DNA from radiation damage in living cells.
Brambilla F, Garcia-Manteiga JM, Monteleone E, Hoelzen L, Zocchi A, Agresti A, Bianchi ME. Brambilla F, et al. Among authors: bianchi me. Nucleic Acids Res. 2020 Sep 18;48(16):8993-9006. doi: 10.1093/nar/gkaa613. Nucleic Acids Res. 2020. PMID: 32710624 Free PMC article.
The acidic intrinsically disordered region of the inflammatory mediator HMGB1 mediates fuzzy interactions with CXCL12.
Mantonico MV, De Leo F, Quilici G, Colley LS, De Marchis F, Crippa M, Mezzapelle R, Schulte T, Zucchelli C, Pastorello C, Carmeno C, Caprioglio F, Ricagno S, Giachin G, Ghitti M, Bianchi ME, Musco G. Mantonico MV, et al. Among authors: bianchi me. Nat Commun. 2024 Feb 8;15(1):1201. doi: 10.1038/s41467-024-45505-7. Nat Commun. 2024. PMID: 38331917 Free PMC article.
217 results