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Synthesis of bioengineered heparin chemically and biologically similar to porcine-derived products and convertible to low MW heparin.
Douaisi M, Paskaleva EE, Fu L, Grover N, McManaman CL, Varghese S, Brodfuehrer PR, Gibson JM, de Joode I, Xia K, Brier MI, Simmons TJ, Datta P, Zhang F, Onishi A, Hirakane M, Mori D, Linhardt RJ, Dordick JS. Douaisi M, et al. Among authors: varghese s. Proc Natl Acad Sci U S A. 2024 Apr 2;121(14):e2315586121. doi: 10.1073/pnas.2315586121. Epub 2024 Mar 18. Proc Natl Acad Sci U S A. 2024. PMID: 38498726 Free PMC article.
Chemobiocatalytic Synthesis of a Low-Molecular-Weight Heparin.
Yu Y, Fu L, He P, Xia K, Varghese S, Wang H, Zhang F, Dordick J, Linhardt RJ. Yu Y, et al. Among authors: varghese s. ACS Chem Biol. 2022 Mar 18;17(3):637-646. doi: 10.1021/acschembio.1c00928. Epub 2022 Feb 24. ACS Chem Biol. 2022. PMID: 35201757
LGR4 is essential for maintaining β-cell homeostasis through suppression of RANK.
Filipowska J, Cisneros Z, Varghese SS, Leon-Rivera N, Wang P, Kang R, Lu G, Yuan YC, Shih HP, Bhattacharya S, Dhawan S, Garcia-Ocaña A, Kondegowda NG, Vasavada RC. Filipowska J, et al. Among authors: varghese ss. Mol Metab. 2025 Jan 7:102097. doi: 10.1016/j.molmet.2025.102097. Online ahead of print. Mol Metab. 2025. PMID: 39788290 Free article.
Adrenocortical Cancer Cell uptake of Iron Oxide Nanoparticles.
Challapalli RS, Hong C, Sorushanova A, Covarrubias-Zambrano O, Mullen N, Feely S, Covarrubias J, Varghese SN, Hantel C, Owens P, O'Halloran M, Prakash P, Bossmann SH, Dennedy MC. Challapalli RS, et al. Among authors: varghese sn. bioRxiv [Preprint]. 2024 Dec 7:2024.12.04.626790. doi: 10.1101/2024.12.04.626790. bioRxiv. 2024. PMID: 39677699 Free PMC article. Preprint.
932 results