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cGAS deficient mice display premature aging associated with de-repression of LINE1 elements and inflammation.
Martinez JC, Morandini F, Fitzgibbons L, Sieczkiewicz N, Bae SJ, Meadow ME, Hillpot E, Cutting J, Paige V, Biashad SA, Simon M, Sedivy J, Seluanov A, Gorbunova V. Martinez JC, et al. Among authors: morandini f. bioRxiv [Preprint]. 2024 Oct 11:2024.10.10.617645. doi: 10.1101/2024.10.10.617645. bioRxiv. 2024. PMID: 39416083 Free PMC article. Preprint.
Trigonelline is an NAD+ precursor that improves muscle function during ageing and is reduced in human sarcopenia.
Membrez M, Migliavacca E, Christen S, Yaku K, Trieu J, Lee AK, Morandini F, Giner MP, Stiner J, Makarov MV, Garratt ES, Vasiloglou MF, Chanvillard L, Dalbram E, Ehrlich AM, Sanchez-Garcia JL, Canto C, Karagounis LG, Treebak JT, Migaud ME, Heshmat R, Razi F, Karnani N, Ostovar A, Farzadfar F, Tay SKH, Sanders MJ, Lillycrop KA, Godfrey KM, Nakagawa T, Moco S, Koopman R, Lynch GS, Sorrentino V, Feige JN. Membrez M, et al. Among authors: morandini f. Nat Metab. 2024 Mar;6(3):433-447. doi: 10.1038/s42255-024-00997-x. Epub 2024 Mar 19. Nat Metab. 2024. PMID: 38504132 Free PMC article.
Slow and steady lives the longest.
Morandini F, Seluanov A, Gorbunova V. Morandini F, et al. Nat Aging. 2024 Jan;4(1):7-9. doi: 10.1038/s43587-023-00554-3. Nat Aging. 2024. PMID: 38191688 No abstract available.
ATAC-clock: An aging clock based on chromatin accessibility.
Morandini F, Rechsteiner C, Perez K, Praz V, Lopez Garcia G, Hinte LC, von Meyenn F, Ocampo A. Morandini F, et al. Geroscience. 2024 Apr;46(2):1789-1806. doi: 10.1007/s11357-023-00986-0. Epub 2023 Nov 4. Geroscience. 2024. PMID: 37924441 Free PMC article.
38 results