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Page 1
The Abca7V1613M variant reduces Aβ generation, plaque load, and neuronal damage.
Butler CA, Mendoza Arvilla A, Milinkeviciute G, Da Cunha C, Kawauchi S, Rezaie N, Liang HY, Javonillo D, Thach A, Wang S, Collins S, Walker A, Shi KX, Neumann J, Gomez-Arboledas A, Henningfield CM, Hohsfield LA, Mapstone M, Tenner AJ, LaFerla FM, Mortazavi A, MacGregor GR, Green KN. Butler CA, et al. Among authors: macgregor gr. Alzheimers Dement. 2024 Jul;20(7):4914-4934. doi: 10.1002/alz.13783. Epub 2024 Mar 20. Alzheimers Dement. 2024. PMID: 38506634 Free PMC article.
A Trem2R47H mouse model without cryptic splicing drives age- and disease-dependent tissue damage and synaptic loss in response to plaques.
Tran KM, Kawauchi S, Kramár EA, Rezaie N, Liang HY, Sakr JS, Gomez-Arboledas A, Arreola MA, Cunha CD, Phan J, Wang S, Collins S, Walker A, Shi KX, Neumann J, Filimban G, Shi Z, Milinkeviciute G, Javonillo DI, Tran K, Gantuz M, Forner S, Swarup V, Tenner AJ, LaFerla FM, Wood MA, Mortazavi A, MacGregor GR, Green KN. Tran KM, et al. Among authors: macgregor gr. Mol Neurodegener. 2023 Feb 17;18(1):12. doi: 10.1186/s13024-023-00598-4. Mol Neurodegener. 2023. PMID: 36803190 Free PMC article.
Single cell spatial transcriptomics reveals distinct patterns of dysregulation in non-neuronal and neuronal cells induced by the Trem2R47H Alzheimer's risk gene mutation.
Johnston K, Berackey BB, Tran KM, Gelber A, Yu Z, MacGregor G, Mukamel EA, Tan Z, Green K, Xu X. Johnston K, et al. Res Sq [Preprint]. 2023 Dec 7:rs.3.rs-3656139. doi: 10.21203/rs.3.rs-3656139/v1. Res Sq. 2023. Update in: Mol Psychiatry. 2025 Feb;30(2):461-477. doi: 10.1038/s41380-024-02651-0 PMID: 38106071 Free PMC article. Updated. Preprint.
Genetic diversity promotes resilience in a mouse model of Alzheimer's disease.
Soni N, Hohsfield LA, Tran KM, Kawauchi S, Walker A, Javonillo D, Phan J, Matheos D, Da Cunha C, Uyar A, Milinkeviciute G, Gomez-Arboledas A, Tran K, Kaczorowski CC, Wood MA, Tenner AJ, LaFerla FM, Carter GW, Mortazavi A, Swarup V, MacGregor GR, Green KN. Soni N, et al. Among authors: macgregor gr. Alzheimers Dement. 2024 Apr;20(4):2794-2816. doi: 10.1002/alz.13753. Epub 2024 Mar 1. Alzheimers Dement. 2024. PMID: 38426371 Free PMC article.
BIN1K358R suppresses glial response to plaques in mouse model of Alzheimer's disease.
Garcia-Agudo LF, Shi Z, Smith IF, Kramár EA, Tran K, Kawauchi S, Wang S, Collins S, Walker A, Shi KX, Neumann J, Liang HY, Da Cunha C, Milinkeviciute G, Morabito S, Miyoshi E, Rezaie N, Gomez-Arboledas A, Arvilla AM, Ghaemi DI, Tenner AJ, LaFerla FM, Wood MA, Mortazavi A, Swarup V, MacGregor GR, Green KN. Garcia-Agudo LF, et al. Among authors: macgregor gr. Alzheimers Dement. 2024 Apr;20(4):2922-2942. doi: 10.1002/alz.13767. Epub 2024 Mar 9. Alzheimers Dement. 2024. PMID: 38460121 Free PMC article.
Sex-specific associations between AD genotype and the microbiome of human amyloid beta knock-in (hAβ-KI) mice.
Dunham SJB, Avelar-Barragan J, Rothman JA, Adams ED, Faraci G, Forner S, Kawauchi S, Tenner AJ, Green KN, LaFerla FM, MacGregor GR, Mapstone M, Whiteson KL. Dunham SJB, et al. Among authors: macgregor gr. Alzheimers Dement. 2024 Jul;20(7):4935-4950. doi: 10.1002/alz.13794. Epub 2024 Apr 4. Alzheimers Dement. 2024. PMID: 38572865 Free PMC article.
APOE Christchurch enhances a disease-associated microglial response to plaque but suppresses response to tau pathology.
Tran KM, Kwang N, Gomez-Arboledas A, Kawauchi S, Mar C, Chao D, Da Cunha C, Wang S, Collins S, Walker A, Shi KX, Alcantara JA, Neumann J, Tenner AJ, LaFerla FM, Hohsfield LA, Swarup V, MacGregor GR, Green KN. Tran KM, et al. Among authors: macgregor gr. bioRxiv [Preprint]. 2024 Jun 4:2024.06.03.597211. doi: 10.1101/2024.06.03.597211. bioRxiv. 2024. PMID: 38895362 Free PMC article. Preprint.
Single-cell spatial transcriptomics reveals distinct patterns of dysregulation in non-neuronal and neuronal cells induced by the Trem2R47H Alzheimer's risk gene mutation.
Johnston KG, Berackey BT, Tran KM, Gelber A, Yu Z, MacGregor GR, Mukamel EA, Tan Z, Green KN, Xu X. Johnston KG, et al. Among authors: macgregor gr. Mol Psychiatry. 2025 Feb;30(2):461-477. doi: 10.1038/s41380-024-02651-0. Epub 2024 Aug 5. Mol Psychiatry. 2025. PMID: 39103533 Free PMC article.
[No title available]
[No authors listed] [No authors listed] PMID: 39750753
76 results