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126 results

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Page 1
The AMPK-related kinase NUAK1 controls cortical axons branching by locally modulating mitochondrial metabolic functions.
Lanfranchi M, Yandiev S, Meyer-Dilhet G, Ellouze S, Kerkhofs M, Dos Reis R, Garcia A, Blondet C, Amar A, Kneppers A, Polvèche H, Plassard D, Foretz M, Viollet B, Sakamoto K, Mounier R, Bourgeois CF, Raineteau O, Goillot E, Courchet J. Lanfranchi M, et al. Among authors: kerkhofs m. Nat Commun. 2024 Mar 21;15(1):2487. doi: 10.1038/s41467-024-46146-6. Nat Commun. 2024. PMID: 38514619 Free PMC article.
Monoallelic de novo variants in DDX17 cause a neurodevelopmental disorder.
Seaby EG, Godwin A, Meyer-Dilhet G, Clerc V, Grand X, Fletcher T, Monteiro L, Kerkhofs M, Carelli V, Palombo F, Seri M, Olivucci G, Grippa M, Ciaccio C, D'Arrigo S, Iascone M, Bermudez M, Fischer J, Di Donato N, Goesswein S, Leung ML, Koboldt DC, Myers C, Arnadottir GA, Stefansson K, Sulem P, Goldberg EM, Bruel AL, Tran Mau Them F, Willems M, Bjornsson HT, Hognason HB, Thorolfsdottir ET, Agolini E, Novelli A, Zampino G, Onesimo R, Lachlan K, Baralle D, Rehm HL, O'Donnell-Luria A, Courchet J, Guille M, Bourgeois CF, Ennis S. Seaby EG, et al. Among authors: kerkhofs m. Brain. 2024 Oct 15:awae320. doi: 10.1093/brain/awae320. Online ahead of print. Brain. 2024. PMID: 39405200
Epigenetic and Genomic Hallmarks of PARP-Inhibitor Resistance in Ovarian Cancer Patients.
Senturk Kirmizitas T, van den Berg C, Boers R, Helmijr J, Makrodimitris S, Dag HH, Kerkhofs M, Beaufort C, Kraan J, van IJcken WFJ, Gribnau J, Garkhail P, Boer GN, Roes EM, van Beekhuizen H, Gunel T, Wilting S, Martens J, Jansen M, Boere I. Senturk Kirmizitas T, et al. Among authors: kerkhofs m. Genes (Basel). 2024 Jun 7;15(6):750. doi: 10.3390/genes15060750. Genes (Basel). 2024. PMID: 38927686 Free PMC article.
Intracellular BAPTA directly inhibits PFKFB3, thereby impeding mTORC1-driven Mcl-1 translation and killing MCL-1-addicted cancer cells.
Sneyers F, Kerkhofs M, Speelman-Rooms F, Welkenhuyzen K, La Rovere R, Shemy A, Voet A, Eelen G, Dewerchin M, Tait SWG, Ghesquière B, Bootman MD, Bultynck G. Sneyers F, et al. Among authors: kerkhofs m. Cell Death Dis. 2023 Sep 8;14(9):600. doi: 10.1038/s41419-023-06120-4. Cell Death Dis. 2023. PMID: 37684238 Free PMC article.
The ER-mitochondria interface, where Ca2+ and cell death meet.
de Ridder I, Kerkhofs M, Lemos FO, Loncke J, Bultynck G, Parys JB. de Ridder I, et al. Among authors: kerkhofs m. Cell Calcium. 2023 Jun;112:102743. doi: 10.1016/j.ceca.2023.102743. Epub 2023 Apr 25. Cell Calcium. 2023. PMID: 37126911 Review.
A non-canonical role for pyruvate kinase M2 as a functional modulator of Ca2+ signalling through IP3 receptors.
Lavik AR, McColl KS, Lemos FO, Kerkhofs M, Zhong F, Harr M, Schlatzer D, Hamada K, Mikoshiba K, Crea F, Bultynck G, Bootman MD, Parys JB, Distelhorst CW. Lavik AR, et al. Among authors: kerkhofs m. Biochim Biophys Acta Mol Cell Res. 2022 Apr;1869(4):119206. doi: 10.1016/j.bbamcr.2021.119206. Epub 2022 Jan 11. Biochim Biophys Acta Mol Cell Res. 2022. PMID: 35026348 Free article.
Getting old without type 2 IP3 receptors.
Kerkhofs M, Bultynck G. Kerkhofs M, et al. Cell Calcium. 2021 Sep;98:102437. doi: 10.1016/j.ceca.2021.102437. Epub 2021 Jun 24. Cell Calcium. 2021. PMID: 34252746 No abstract available.
126 results