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Lipid nanoparticles and transcranial focused ultrasound enhance the delivery of SOD1 antisense oligonucleotides to the murine brain for ALS therapy.
Ediriweera GR, Sivaram AJ, Cowin G, Brown ML, McAlary L, Lum JS, Fletcher NL, Robinson L, Simpson JD, Chen L, Wasielewska JM, Byrne E, Finnie JW, Manavis J, White AR, Yerbury JJ, Thurecht KJ, Vine KL. Ediriweera GR, et al. Among authors: mcalary l. J Control Release. 2024 Dec 12;378:221-235. doi: 10.1016/j.jconrel.2024.11.074. Online ahead of print. J Control Release. 2024. PMID: 39645085 Free article.
Rapid classification of a novel ALS-causing I149S variant in superoxide dismutase-1.
Shephard VK, Brown ML, Thompson BA, Harpur A, McAlary L. Shephard VK, et al. Among authors: mcalary l. Amyotroph Lateral Scler Frontotemporal Degener. 2024 Aug;25(5-6):608-614. doi: 10.1080/21678421.2024.2351177. Epub 2024 May 14. Amyotroph Lateral Scler Frontotemporal Degener. 2024. PMID: 38742757 Free article.
Evaluating protein cross-linking as a therapeutic strategy to stabilize SOD1 variants in a mouse model of familial ALS.
Hossain MA, Sarin R, Donnelly DP, Miller BC, Weiss A, McAlary L, Antonyuk SV, Salisbury JP, Amin J, Conway JB, Watson SS, Winters JN, Xu Y, Alam N, Brahme RR, Shahbazian H, Sivasankar D, Padmakumar S, Sattarova A, Ponmudiyan AC, Gawde T, Verrill DE, Yang W, Kannapadi S, Plant LD, Auclair JR, Makowski L, Petsko GA, Ringe D, Agar NYR, Greenblatt DJ, Ondrechen MJ, Chen Y, Yerbury JJ, Manetsch R, Hasnain SS, Brown RH Jr, Agar JN. Hossain MA, et al. Among authors: mcalary l. PLoS Biol. 2024 Jan 30;22(1):e3002462. doi: 10.1371/journal.pbio.3002462. eCollection 2024 Jan. PLoS Biol. 2024. PMID: 38289969 Free PMC article.
ALS-linked CCNF variant disrupts motor neuron ubiquitin homeostasis.
Farrawell NE, Bax M, McAlary L, McKenna J, Maksour S, Do-Ha D, Rayner SL, Blair IP, Chung RS, Yerbury JJ, Ooi L, Saunders DN. Farrawell NE, et al. Among authors: mcalary l. Hum Mol Genet. 2023 Jul 4;32(14):2386-2398. doi: 10.1093/hmg/ddad063. Hum Mol Genet. 2023. PMID: 37220877 Free PMC article.
36 results