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Blocking matrix metalloproteinase-mediated syndecan-4 shedding restores the endothelial glycocalyx and glomerular filtration barrier function in early diabetic kidney disease.
Ramnath RD, Butler MJ, Newman G, Desideri S, Russell A, Lay AC, Neal CR, Qiu Y, Fawaz S, Onions KL, Gamez M, Crompton M, Michie C, Finch N, Coward RJ, Welsh GI, Foster RR, Satchell SC. Ramnath RD, et al. Among authors: butler mj. Kidney Int. 2020 May;97(5):951-965. doi: 10.1016/j.kint.2019.09.035. Epub 2019 Nov 2. Kidney Int. 2020. PMID: 32037077 Free PMC article.
Reduced Glomerular Filtration in Diabetes Is Attributable to Loss of Density and Increased Resistance of Glomerular Endothelial Cell Fenestrations.
Finch NC, Fawaz SS, Neal CR, Butler MJ, Lee VK, Salmon AJ, Lay AC, Stevens M, Dayalan L, Band H, Mellor HH, Harper SJ, Shima DT, Welsh GI, Foster RR, Satchell SC. Finch NC, et al. Among authors: butler mj. J Am Soc Nephrol. 2022 Jun;33(6):1120-1136. doi: 10.1681/ASN.2021030294. Epub 2022 Mar 15. J Am Soc Nephrol. 2022. PMID: 35292439 Free PMC article.
Mineralocorticoid receptor antagonism in diabetes reduces albuminuria by preserving the glomerular endothelial glycocalyx.
Crompton M, Ferguson JK, Ramnath RD, Onions KL, Ogier AS, Gamez M, Down CJ, Skinner L, Wong KH, Dixon LK, Sutak J, Harper SJ, Pontrelli P, Gesualdo L, Heerspink HL, Toto RD, Welsh GI, Foster RR, Satchell SC, Butler MJ. Crompton M, et al. Among authors: butler mj. JCI Insight. 2023 Mar 8;8(5):e154164. doi: 10.1172/jci.insight.154164. JCI Insight. 2023. PMID: 36749631 Free PMC article. Clinical Trial.
Heparanase inhibition as a systemic approach to protect the endothelial glycocalyx and prevent microvascular complications in diabetes.
Gamez M, Elhegni HE, Fawaz S, Ho KH, Campbell NW, Copland DA, Onions KL, Butler MJ, Wasson EJ, Crompton M, Ramnath RD, Qiu Y, Yamaguchi Y, Arkill KP, Bates DO, Turnbull JE, Zubkova OV, Welsh GI, Atan D, Satchell SC, Foster RR. Gamez M, et al. Among authors: butler mj. Cardiovasc Diabetol. 2024 Feb 1;23(1):50. doi: 10.1186/s12933-024-02133-1. Cardiovasc Diabetol. 2024. PMID: 38302978 Free PMC article.
A novel assay provides sensitive measurement of physiologically relevant changes in albumin permeability in isolated human and rodent glomeruli.
Desideri S, Onions KL, Qiu Y, Ramnath RD, Butler MJ, Neal CR, King MLR, Salmon AE, Saleem MA, Welsh GI, Michel CC, Satchell SC, Salmon AHJ, Foster RR. Desideri S, et al. Among authors: butler mj. Kidney Int. 2018 May;93(5):1086-1097. doi: 10.1016/j.kint.2017.12.003. Epub 2018 Feb 9. Kidney Int. 2018. PMID: 29433915 Free PMC article.
The authors reply.
Ramnath RD, Butler MJ, Foster RR, Satchell SC. Ramnath RD, et al. Among authors: butler mj. Kidney Int. 2020 May;97(5):1057-1058. doi: 10.1016/j.kint.2020.02.006. Kidney Int. 2020. PMID: 32331580 Free PMC article. No abstract available.
177 results