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Nuclear and cytosolic fractions of SOX2 synergize as transcriptional and translational co-regulators of cell fate.
Schaefer T, Mittal N, Wang H, Ataman M, Candido S, Lötscher J, Velychko S, Tintignac L, Bock T, Börsch A, Baßler J, Rao TN, Zmajkovic J, Roffeis S, Löliger J, Jacob F, Dumlin A, Schürch C, Schmidt A, Skoda RC, Wymann MP, Hess C, Schöler HR, Zaehres H, Hurt E, Zavolan M, Lengerke C. Schaefer T, et al. Among authors: velychko s. Cell Rep. 2024 Oct 22;43(10):114807. doi: 10.1016/j.celrep.2024.114807. Epub 2024 Oct 3. Cell Rep. 2024. PMID: 39368083 Free article.
Highly cooperative chimeric super-SOX induces naive pluripotency across species.
MacCarthy CM, Wu G, Malik V, Menuchin-Lasowski Y, Velychko T, Keshet G, Fan R, Bedzhov I, Church GM, Jauch R, Cojocaru V, Schöler HR, Velychko S. MacCarthy CM, et al. Among authors: velychko s. Cell Stem Cell. 2024 Jan 4;31(1):127-147.e9. doi: 10.1016/j.stem.2023.11.010. Epub 2023 Dec 22. Cell Stem Cell. 2024. PMID: 38141611 Free article.
Impaired neuron differentiation in GBA-associated Parkinson's disease is linked to cell cycle defects in organoids.
Rosety I, Zagare A, Saraiva C, Nickels S, Antony P, Almeida C, Glaab E, Halder R, Velychko S, Rauen T, Schöler HR, Bolognin S, Sauter T, Jarazo J, Krüger R, Schwamborn JC. Rosety I, et al. Among authors: velychko s. NPJ Parkinsons Dis. 2023 Dec 18;9(1):166. doi: 10.1038/s41531-023-00616-8. NPJ Parkinsons Dis. 2023. PMID: 38110400 Free PMC article.
One-step Reprogramming of Human Fibroblasts into Oligodendrocyte-like Cells by SOX10, OLIG2, and NKX6.2.
Chanoumidou K, Hernández-Rodríguez B, Windener F, Thomas C, Stehling M, Mozafari S, Albrecht S, Ottoboni L, Antel J, Kim KP, Velychko S, Cui QL, Xu YKT, Martino G, Winkler J, Schöler HR, Baron-Van Evercooren A, Boespflug-Tanguy O, Vaquerizas JM, Ehrlich M, Kuhlmann T. Chanoumidou K, et al. Among authors: velychko s. Stem Cell Reports. 2021 Apr 13;16(4):771-783. doi: 10.1016/j.stemcr.2021.03.001. Epub 2021 Mar 25. Stem Cell Reports. 2021. PMID: 33770499 Free PMC article.
Directed Evolution of an Enhanced POU Reprogramming Factor for Cell Fate Engineering.
Tan DS, Chen Y, Gao Y, Bednarz A, Wei Y, Malik V, Ho DH, Weng M, Ho SY, Srivastava Y, Velychko S, Yang X, Fan L, Kim J, Graumann J, Stormo GD, Braun T, Yan J, Schöler HR, Jauch R. Tan DS, et al. Among authors: velychko s. Mol Biol Evol. 2021 Jun 25;38(7):2854-2868. doi: 10.1093/molbev/msab075. Mol Biol Evol. 2021. PMID: 33720298 Free PMC article.
Reprogramming competence of OCT factors is determined by transactivation domains.
Kim KP, Wu Y, Yoon J, Adachi K, Wu G, Velychko S, MacCarthy CM, Shin B, Röpke A, Arauzo-Bravo MJ, Stehling M, Han DW, Gao Y, Kim J, Gao S, Schöler HR. Kim KP, et al. Among authors: velychko s. Sci Adv. 2020 Sep 2;6(36):eaaz7364. doi: 10.1126/sciadv.aaz7364. Print 2020 Sep. Sci Adv. 2020. PMID: 32917606 Free PMC article.
R-loops coordinate with SOX2 in regulating reprogramming to pluripotency.
Li Y, Song Y, Xu W, Li Q, Wang X, Li K, Wang J, Liu Z, Velychko S, Ye R, Xia Q, Wang L, Guo R, Dong X, Zheng Z, Dai Y, Li H, Yao M, Xue Y, Schöler HR, Sun Q, Yao H. Li Y, et al. Among authors: velychko s. Sci Adv. 2020 Jun 10;6(24):eaba0777. doi: 10.1126/sciadv.aba0777. eCollection 2020 Jun. Sci Adv. 2020. PMID: 32704541 Free PMC article.
16 results