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The IRG1-itaconate axis protects from cholesterol-induced inflammation and atherosclerosis.
Cyr Y, Bozal FK, Barcia Durán JG, Newman AAC, Amadori L, Smyrnis P, Gourvest M, Das D, Gildea M, Kaur R, Zhang T, Wang KM, Von Itter R, Schlegel PM, Dupuis SD, Sanchez BF, Schmidt AM, Fisher EA, van Solingen C, Giannarelli C, Moore KJ. Cyr Y, et al. Among authors: giannarelli c. Proc Natl Acad Sci U S A. 2024 Apr 9;121(15):e2400675121. doi: 10.1073/pnas.2400675121. Epub 2024 Apr 2. Proc Natl Acad Sci U S A. 2024. PMID: 38564634 Free PMC article.
Systems immunology-based drug repurposing framework to target inflammation in atherosclerosis.
Amadori L, Calcagno C, Fernandez DM, Koplev S, Fernandez N, Kaur R, Mury P, Khan NS, Sajja S, Shamailova R, Cyr Y, Jeon M, Hill CA, Chong PS, Naidu S, Sakurai K, Ghotbi AA, Soler R, Eberhardt N, Rahman A, Faries P, Moore KJ, Fayad ZA, Ma'ayan A, Giannarelli C. Amadori L, et al. Among authors: giannarelli c. Nat Cardiovasc Res. 2023 Jun;2(6):550-571. doi: 10.1038/s44161-023-00278-y. Epub 2023 Jun 8. Nat Cardiovasc Res. 2023. PMID: 37771373 Free PMC article.
SARS-CoV-2 infection triggers pro-atherogenic inflammatory responses in human coronary vessels.
Eberhardt N, Noval MG, Kaur R, Amadori L, Gildea M, Sajja S, Das D, Cilhoroz B, Stewart O, Fernandez DM, Shamailova R, Guillen AV, Jangra S, Schotsaert M, Newman JD, Faries P, Maldonado T, Rockman C, Rapkiewicz A, Stapleford KA, Narula N, Moore KJ, Giannarelli C. Eberhardt N, et al. Among authors: giannarelli c. Nat Cardiovasc Res. 2023 Oct;2(10):899-916. doi: 10.1038/s44161-023-00336-5. Epub 2023 Sep 28. Nat Cardiovasc Res. 2023. PMID: 38076343 Free PMC article.
Single-cell profiling reveals inflammatory polarization of human carotid versus femoral plaque leukocytes.
Slysz J, Sinha A, DeBerge M, Singh S, Avgousti H, Lee I, Glinton K, Nagasaka R, Dalal P, Alexandria S, Wai CM, Tellez R, Vescovo M, Sunderraj A, Wang X, Schipma M, Sisk R, Gulati R, Vallejo J, Saigusa R, Lloyd-Jones DM, Lomasney J, Weinberg S, Ho K, Ley K, Giannarelli C, Thorp EB, Feinstein MJ. Slysz J, et al. Among authors: giannarelli c. JCI Insight. 2023 Sep 8;8(17):e171359. doi: 10.1172/jci.insight.171359. JCI Insight. 2023. PMID: 37471165 Free PMC article.
BHLHE40/41 regulate macrophage/microglia responses associated with Alzheimer's disease and other disorders of lipid-rich tissues.
Podlesny-Drabiniok A, Novikova G, Liu Y, Dunst J, Temizer R, Giannarelli C, Marro S, Kreslavsky T, Marcora E, Goate AM. Podlesny-Drabiniok A, et al. Among authors: giannarelli c. bioRxiv [Preprint]. 2023 Feb 13:2023.02.13.528372. doi: 10.1101/2023.02.13.528372. bioRxiv. 2023. Update in: Nat Commun. 2024 Mar 6;15(1):2058. doi: 10.1038/s41467-024-46315-7 PMID: 36824752 Free PMC article. Updated. Preprint.
Editorial: Immune and autoimmune mechanisms in cardiovascular disease.
Winkels H, Gerdes N, Kahles F, Dutta P, Giannarelli C, Wolf D. Winkels H, et al. Among authors: giannarelli c. Front Cardiovasc Med. 2023 Jan 9;9:1125959. doi: 10.3389/fcvm.2022.1125959. eCollection 2022. Front Cardiovasc Med. 2023. PMID: 36698960 Free PMC article. No abstract available.
Immune checkpoint landscape of human atherosclerosis and influence of cardiometabolic factors.
Barcia Durán JG, Das D, Gildea M, Amadori L, Gourvest M, Kaur R, Eberhardt N, Smyrnis P, Cilhoroz B, Sajja S, Rahman K, Fernandez DM, Faries P, Narula N, Vanguri R, Goldberg IJ, Fisher EA, Berger JS, Moore KJ, Giannarelli C. Barcia Durán JG, et al. Among authors: giannarelli c. Nat Cardiovasc Res. 2024 Dec;3(12):1482-1502. doi: 10.1038/s44161-024-00563-4. Epub 2024 Nov 29. Nat Cardiovasc Res. 2024. PMID: 39613875 Free PMC article.
91 results