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Direct Modulators of K-Ras-Membrane Interactions.
Morstein J, Shrestha R, Van QN, López CA, Arora N, Tonelli M, Liang H, Chen D, Zhou Y, Hancock JF, Stephen AG, Turbyville TJ, Shokat KM. Morstein J, et al. Among authors: stephen ag. ACS Chem Biol. 2023 Sep 15;18(9):2082-2093. doi: 10.1021/acschembio.3c00413. Epub 2023 Aug 14. ACS Chem Biol. 2023. PMID: 37579045 Free PMC article.
Revealing the mechanism of action of a first-in-class covalent inhibitor of KRASG12C (ON) and other functional properties of oncogenic KRAS by 31P NMR.
Sharma AK, Pei J, Yang Y, Dyba M, Smith B, Rabara D, Larsen EK, Lightstone FC, Esposito D, Stephen AG, Wang B, Beltran PJ, Wallace E, Nissley DV, McCormick F, Maciag AE. Sharma AK, et al. Among authors: stephen ag. J Biol Chem. 2024 Feb;300(2):105650. doi: 10.1016/j.jbc.2024.105650. Epub 2024 Jan 16. J Biol Chem. 2024. PMID: 38237681 Free PMC article.
Progress in Targeting KRAS Directly.
Nissley DV, Stephen AG, Yi M, McCormick F. Nissley DV, et al. Among authors: stephen ag. Methods Mol Biol. 2024;2797:1-12. doi: 10.1007/978-1-0716-3822-4_1. Methods Mol Biol. 2024. PMID: 38570448
Measurement of KRAS-GTPase Activity.
Rabara D, Stephen AG. Rabara D, et al. Among authors: stephen ag. Methods Mol Biol. 2024;2797:91-102. doi: 10.1007/978-1-0716-3822-4_7. Methods Mol Biol. 2024. PMID: 38570454
Determining KRAS4B-Targeting Compound Specificity by Top-Down Mass Spectrometry.
D'Ippolito RA, Scheidemantle GM, Rabara D, Abreu Blanco M, Ramakrishnan N, Widmeyer SRT, Messing S, Turner D, Maciag AE, Stephen AG, Esposito D, McCormick F, Nissley DV, DeHart CJ. D'Ippolito RA, et al. Among authors: stephen ag. Methods Mol Biol. 2024;2823:291-310. doi: 10.1007/978-1-0716-3922-1_18. Methods Mol Biol. 2024. PMID: 39052227
Comprehensive structure-function analysis reveals gain- and loss-of-function mechanisms impacting oncogenic KRAS activity.
Kwon JJ, Dilly J, Liu S, Kim E, Bian Y, Dharmaiah S, Tran TH, Kapner KS, Ly SH, Yang X, Rabara D, Waybright TJ, Giacomelli AO, Hong AL, Misek S, Wang B, Ravi A, Doench JG, Beroukhim R, Lemke CT, Haigis KM, Esposito D, Root DE, Nissley DV, Stephen AG, McCormick F, Simanshu DK, Hahn WC, Aguirre AJ. Kwon JJ, et al. Among authors: stephen ag. bioRxiv [Preprint]. 2024 Oct 25:2024.10.22.618529. doi: 10.1101/2024.10.22.618529. bioRxiv. 2024. PMID: 39484452 Free PMC article. Preprint.
96 results