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Homozygous might be hemizygous: CRISPR/Cas9 editing in iPSCs results in detrimental on-target defects that escape standard quality controls.
Simkin D, Papakis V, Bustos BI, Ambrosi CM, Ryan SJ, Baru V, Williams LA, Dempsey GT, McManus OB, Landers JE, Lubbe SJ, George AL Jr, Kiskinis E. Simkin D, et al. Among authors: kiskinis e. Stem Cell Reports. 2022 Apr 12;17(4):993-1008. doi: 10.1016/j.stemcr.2022.02.008. Epub 2022 Mar 10. Stem Cell Reports. 2022. PMID: 35276091 Free PMC article.
Somatic coding mutations in human induced pluripotent stem cells.
Gore A, Li Z, Fung HL, Young JE, Agarwal S, Antosiewicz-Bourget J, Canto I, Giorgetti A, Israel MA, Kiskinis E, Lee JH, Loh YH, Manos PD, Montserrat N, Panopoulos AD, Ruiz S, Wilbert ML, Yu J, Kirkness EF, Izpisua Belmonte JC, Rossi DJ, Thomson JA, Eggan K, Daley GQ, Goldstein LS, Zhang K. Gore A, et al. Among authors: kiskinis e. Nature. 2011 Mar 3;471(7336):63-7. doi: 10.1038/nature09805. Nature. 2011. PMID: 21368825 Free PMC article.
Identification of BAF57 mutations in human breast cancer cell lines.
Kiskinis E, García-Pedrero JM, Villaronga MA, Parker MG, Belandia B. Kiskinis E, et al. Breast Cancer Res Treat. 2006 Jul;98(2):191-8. doi: 10.1007/s10549-005-9149-9. Epub 2006 Mar 15. Breast Cancer Res Treat. 2006. PMID: 16538531 Free article.
Peptide-siRNA Supramolecular Particles for Neural Cell Transfection.
Hernandez-Garcia A, Álvarez Z, Simkin D, Madhan A, Pariset E, Tantakitti F, de J Vargas-Dorantes O, Lee SS, Kiskinis E, Stupp SI. Hernandez-Garcia A, et al. Among authors: kiskinis e. Adv Sci (Weinh). 2018 Dec 5;6(3):1801458. doi: 10.1002/advs.201801458. eCollection 2019 Feb 6. Adv Sci (Weinh). 2018. PMID: 30775231 Free PMC article.
Effect of Ezogabine on Cortical and Spinal Motor Neuron Excitability in Amyotrophic Lateral Sclerosis: A Randomized Clinical Trial.
Wainger BJ, Macklin EA, Vucic S, McIlduff CE, Paganoni S, Maragakis NJ, Bedlack R, Goyal NA, Rutkove SB, Lange DJ, Rivner MH, Goutman SA, Ladha SS, Mauricio EA, Baloh RH, Simmons Z, Pothier L, Kassis SB, La T, Hall M, Evora A, Klements D, Hurtado A, Pereira JD, Koh J, Celnik PA, Chaudhry V, Gable K, Juel VC, Phielipp N, Marei A, Rosenquist P, Meehan S, Oskarsson B, Lewis RA, Kaur D, Kiskinis E, Woolf CJ, Eggan K, Weiss MD, Berry JD, David WS, Davila-Perez P, Camprodon JA, Pascual-Leone A, Kiernan MC, Shefner JM, Atassi N, Cudkowicz ME. Wainger BJ, et al. Among authors: kiskinis e. JAMA Neurol. 2021 Feb 1;78(2):186-196. doi: 10.1001/jamaneurol.2020.4300. JAMA Neurol. 2021. PMID: 33226425 Free PMC article. Clinical Trial.
64 results