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Discovery of 2-Amide-3-methylester Thiophenes that Target SARS-CoV-2 Mac1 and Repress Coronavirus Replication, Validating Mac1 as an Antiviral Target.
Wazir S, Parviainen TAO, Pfannenstiel JJ, Duong MTH, Cluff D, Sowa ST, Galera-Prat A, Ferraris D, Maksimainen MM, Fehr AR, Heiskanen JP, Lehtiö L. Wazir S, et al. Among authors: heiskanen jp. J Med Chem. 2024 Apr 25;67(8):6519-6536. doi: 10.1021/acs.jmedchem.3c02451. Epub 2024 Apr 9. J Med Chem. 2024. PMID: 38592023
Analogs of TIQ-A as inhibitors of human mono-ADP-ribosylating PARPs.
Maksimainen MM, Murthy S, Sowa ST, Galera-Prat A, Rolina E, Heiskanen JP, Lehtiö L. Maksimainen MM, et al. Among authors: heiskanen jp. Bioorg Med Chem. 2021 Dec 15;52:116511. doi: 10.1016/j.bmc.2021.116511. Epub 2021 Nov 10. Bioorg Med Chem. 2021. PMID: 34801828 Free article.
Discovery of 2-amide-3-methylester thiophenes that target SARS-CoV-2 Mac1 and repress coronavirus replication, validating Mac1 as an anti-viral target.
Wazir S, Parviainen TAO, Pfannenstiel JJ, Duong MTH, Cluff D, Sowa ST, Galera-Prat A, Ferraris D, Maksimainen MM, Fehr AR, Heiskanen JP, Lehtiö L. Wazir S, et al. Among authors: heiskanen jp. bioRxiv [Preprint]. 2023 Dec 27:2023.08.28.555062. doi: 10.1101/2023.08.28.555062. bioRxiv. 2023. Update in: J Med Chem. 2024 Apr 25;67(8):6519-6536. doi: 10.1021/acs.jmedchem.3c02451 PMID: 38234730 Free PMC article. Updated. Preprint.
High Oxygen Barrier Polyester from 3,3'-Bifuran-5,5'-dicarboxylic Acid.
Kainulainen TP, Parviainen TAO, Sirviö JA, McGeachie LJR, Heiskanen JP. Kainulainen TP, et al. Among authors: heiskanen jp. ACS Macro Lett. 2023 Feb 21;12(2):147-151. doi: 10.1021/acsmacrolett.2c00743. Epub 2023 Jan 13. ACS Macro Lett. 2023. PMID: 36638046 Free PMC article.
Synthesis of 4-alkoxy-8-hydroxyquinolines.
Heiskanen JP, Omar WA, Ylikunnari MK, Haavisto KM, Juan MJ, Hormi OE. Heiskanen JP, et al. J Org Chem. 2007 Feb 2;72(3):920-2. doi: 10.1021/jo062175i. J Org Chem. 2007. PMID: 17253811
19 results