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Page 1
Combined inhibition of IL-1, IL-33 and IL-36 signalling by targeting IL1RAP ameliorates skin and lung fibrosis in preclinical models of systemic sclerosis.
Grönberg C, Rattik S, Tran-Manh C, Zhou X, Rius Rigau A, Li YN, Györfi AH, Dickel N, Kunz M, Kreuter A, Matei EA, Zhu H, Skoog P, Liberg D, Distler JH, Trinh-Minh T. Grönberg C, et al. Ann Rheum Dis. 2024 Aug 27;83(9):1156-1168. doi: 10.1136/ard-2023-225158. Ann Rheum Dis. 2024. PMID: 38594058 Free PMC article.
Antibodies targeting the shared cytokine receptor IL-1 receptor accessory protein invoke distinct mechanisms to block all cytokine signaling.
Fields JK, Gyllenbäck EJ, Bogacz M, Obi J, Birkedal GS, Sjöström K, Maravillas K, Grönberg C, Rattik S, Kihn K, Flowers M, Smith AK, Hansen N, Fioretos T, Huyhn C, Liberg D, Deredge D, Sundberg EJ. Fields JK, et al. Among authors: gronberg c. Cell Rep. 2024 May 28;43(5):114099. doi: 10.1016/j.celrep.2024.114099. Epub 2024 Apr 17. Cell Rep. 2024. PMID: 38636519 Free PMC article.
IL1RAP Blockade With a Monoclonal Antibody Reduces Cardiac Inflammation and Preserves Heart Function in Viral and Autoimmune Myocarditis.
Lema DA, Jakobsson G, Daoud A, Elias D, Talor MV, Rattik S, Grönberg C, Kalinoski H, Jaensson Gyllenbäck E, Wang N, Liberg D, Schiopu A, Čiháková D. Lema DA, et al. Among authors: gronberg c. Circ Heart Fail. 2024 Dec;17(12):e011729. doi: 10.1161/CIRCHEARTFAILURE.124.011729. Epub 2024 Nov 8. Circ Heart Fail. 2024. PMID: 39513273 Free PMC article.
Blocking IL1RAP on cancer-associated fibroblasts in pancreatic ductal adenocarcinoma suppresses IL-1-induced neutrophil recruitment.
Hansen N, Peña-Martínez P, Skoog P, Reinbach K, Hansen FC, Faria SL, Grönberg C, Abdilleh K, Magnusson S, von Wachenfeldt K, Millrud CR, Liberg D, Järås M. Hansen N, et al. Among authors: gronberg c. J Immunother Cancer. 2024 Dec 18;12(12):e009523. doi: 10.1136/jitc-2024-009523. J Immunother Cancer. 2024. PMID: 39694705 Free PMC article.
The hepatitis C virus envelope protein complex is a dimer of heterodimers.
Augestad EH, Holmboe Olesen C, Grønberg C, Soerensen A, Velázquez-Moctezuma R, Fanalista M, Bukh J, Wang K, Gourdon P, Prentoe J. Augestad EH, et al. Among authors: gronberg c. Nature. 2024 Sep;633(8030):704-709. doi: 10.1038/s41586-024-07783-5. Epub 2024 Sep 4. Nature. 2024. PMID: 39232163
Interleukin-1 receptor accessory protein blockade limits the development of atherosclerosis and reduces plaque inflammation.
Mulholland M, Depuydt MAC, Jakobsson G, Ljungcrantz I, Grentzmann A, To F, Bengtsson E, Jaensson Gyllenbäck E, Grönberg C, Rattik S, Liberg D, Schiopu A, Björkbacka H, Kuiper J, Bot I, Slütter B, Engelbertsen D. Mulholland M, et al. Among authors: gronberg c. Cardiovasc Res. 2024 May 7;120(6):581-595. doi: 10.1093/cvr/cvae046. Cardiovasc Res. 2024. PMID: 38563353 Free PMC article.
Structural basis of ion uptake in copper-transporting P1B-type ATPases.
Salustros N, Grønberg C, Abeyrathna NS, Lyu P, Orädd F, Wang K, Andersson M, Meloni G, Gourdon P. Salustros N, et al. Among authors: gronberg c. Nat Commun. 2022 Aug 31;13(1):5121. doi: 10.1038/s41467-022-32751-w. Nat Commun. 2022. PMID: 36045128 Free PMC article.
Blockade of IL-1α and IL-1β signaling by the anti-IL1RAP antibody nadunolimab (CAN04) mediates synergistic anti-tumor efficacy with chemotherapy.
Rydberg Millrud C, Deronic A, Grönberg C, Jaensson Gyllenbäck E, von Wachenfeldt K, Forsberg G, Liberg D. Rydberg Millrud C, et al. Among authors: gronberg c. Cancer Immunol Immunother. 2023 Mar;72(3):667-678. doi: 10.1007/s00262-022-03277-3. Epub 2022 Aug 29. Cancer Immunol Immunother. 2023. PMID: 36036818 Free PMC article.
28 results