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The replication-competent HIV reservoir is a genetically restricted, younger subset of the overall pool of HIV proviruses persisting during therapy, which is highly genetically stable over time.
Shahid A, MacLennan S, Jones BR, Sudderuddin H, Dang Z, Cobarrubias K, Duncan MC, Kinloch NN, Dapp MJ, Archin NM, Fischl MA, Ofotokun I, Adimora A, Gange S, Aouizerat B, Kuniholm MH, Kassaye S, Mullins JI, Goldstein H, Joy JB, Anastos K, Brumme ZL; MACS/WIHS combined cohort study (MWCSS). Shahid A, et al. J Virol. 2024 Feb 20;98(2):e0165523. doi: 10.1128/jvi.01655-23. Epub 2024 Jan 12. J Virol. 2024. PMID: 38214547 Free PMC article.
Computationally inferred cell-type specific epigenome-wide DNA methylation analysis unveils distinct methylation patterns among immune cells for HIV infection in three cohorts.
Zhang X, Hu Y, Vandenhoudt RE, Yan C, Marconi VC, Cohen MH, Wang Z, Justice AC, Aouizerat BE, Xu K. Zhang X, et al. Among authors: aouizerat be. PLoS Pathog. 2024 Mar 11;20(3):e1012063. doi: 10.1371/journal.ppat.1012063. eCollection 2024 Mar. PLoS Pathog. 2024. PMID: 38466776 Free PMC article.
Frequent Cocaine Use is Associated With Larger HIV Latent Reservoir Size.
Aouizerat BE, Garcia JN, Domingues CV, Xu K, Quach BC, Page GP, Konkle-Parker D, Bolivar HH, Lahiri CD, Golub ET, Cohen MH, Kassaye SG, DeHovitz J, Kuniholm MH, Archin NM, Tien PC, Hancock DB, Johnson EO. Aouizerat BE, et al. J Acquir Immune Defic Syndr. 2024 Oct 1;97(2):156-164. doi: 10.1097/QAI.0000000000003472. J Acquir Immune Defic Syndr. 2024. PMID: 39250649
HBI: a hierarchical Bayesian interaction model to estimate cell-type-specific methylation quantitative trait loci incorporating priors from cell-sorted bisulfite sequencing data.
Cheng Y, Cai B, Li H, Zhang X, D'Souza G, Shrestha S, Edmonds A, Meyers J, Fischl M, Kassaye S, Anastos K, Cohen M, Aouizerat BE, Xu K, Zhao H. Cheng Y, et al. Among authors: aouizerat be. Genome Biol. 2024 Oct 15;25(1):273. doi: 10.1186/s13059-024-03411-7. Genome Biol. 2024. PMID: 39407252 Free PMC article.
The replication-competent HIV reservoir is a genetically restricted, younger subset of the overall pool of HIV proviruses persisting during therapy, which is highly genetically stable over time.
Shahid A, MacLennan S, Jones BR, Sudderuddin H, Dang Z, Cobamibias K, Duncan MC, Kinloch NN, Dapp MJ, Archin NM, Fischl MA, Ofotokun I, Adimora A, Gange S, Aouizerat B, Kuniholm MH, Kassaye S, Mullins JI, Goldstein H, Joy JB, Anastos K, Brumme ZL. Shahid A, et al. Res Sq [Preprint]. 2023 Aug 16:rs.3.rs-3259040. doi: 10.21203/rs.3.rs-3259040/v1. Res Sq. 2023. Update in: J Virol. 2024 Feb 20;98(2):e0165523. doi: 10.1128/jvi.01655-23 PMID: 37645749 Free PMC article. Updated. Preprint.
225 results