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Page 1
Discovery of Protease-Activated Receptor 4 (PAR4)-Tethered Ligand Antagonists Using Ultralarge Virtual Screening.
Smith ST, Cassada JB, Von Bredow L, Erreger K, Webb EM, Trombley TA, Kalbfleisch JJ, Bender BJ, Zagol-Ikapitte I, Kramlinger VM, Bouchard JL, Mitchell SG, Tretbar M, Shoichet BK, Lindsley CW, Meiler J, Hamm HE. Smith ST, et al. Among authors: bouchard jl. ACS Pharmacol Transl Sci. 2024 Mar 21;7(4):1086-1100. doi: 10.1021/acsptsci.3c00378. eCollection 2024 Apr 12. ACS Pharmacol Transl Sci. 2024. PMID: 38633591
Incorporation of Three Extracyclic Arginine Residues into a Melanocortin Macrocyclic Agonist (c[Pro-His-DPhe-Arg-Trp-Dap-Lys(Arg-Arg-Arg-Ac)-DPro]) Decreases Food Intake When Administered Intrathecally or Subcutaneously Compared to a Macrocyclic Ligand Lacking Extracyclic Arginine Residues (c[Pro-His-DPhe-Arg-Trp-Dap-Ala-DPro)].
Ericson MD, Freeman KT, Larson CM, Bouchard JL, John K, Lunzer MM, Koerperich ZM, Haskell-Luevano C. Ericson MD, et al. Among authors: bouchard jl. ACS Pharmacol Transl Sci. 2024 Apr 2;7(4):1114-1125. doi: 10.1021/acsptsci.4c00011. eCollection 2024 Apr 12. ACS Pharmacol Transl Sci. 2024. PMID: 38633589
Classics in Chemical Neuroscience: Medetomidine.
de Andrade Horn P, Berida TI, Parr LC, Bouchard JL, Jayakodiarachchi N, Schultz DC, Lindsley CW, Crowley ML. de Andrade Horn P, et al. Among authors: bouchard jl. ACS Chem Neurosci. 2024 Nov 6;15(21):3874-3883. doi: 10.1021/acschemneuro.4c00583. Epub 2024 Oct 15. ACS Chem Neurosci. 2024. PMID: 39405508 Free PMC article. Review.
What Is Pink Cocaine? The Dark Reality behind a Colorful Name.
Barbaro L, Bouchard JL. Barbaro L, et al. Among authors: bouchard jl. J Med Chem. 2024 Dec 12;67(23):20733-20736. doi: 10.1021/acs.jmedchem.4c02821. Epub 2024 Dec 3. J Med Chem. 2024. PMID: 39624978 No abstract available.
Discovery of a Pan-Melanocortin Receptor Antagonist [Ac-DPhe(pI)-Arg-Nal(2')-Orn-NH2] at the MC1R, MC3R, MC4R, and MC5R that Mediates an Increased Feeding Response in Mice and a 40-Fold Selective MC1R Antagonist [Ac-DPhe(pI)-DArg-Nal(2')-Arg-NH2].
Ericson MD, Tran LT, Mathre SS, Freeman KT, Holdaway K, John K, Lunzer MM, Bouchard JL, Haskell-Luevano C. Ericson MD, et al. Among authors: bouchard jl. J Med Chem. 2023 Jun 22;66(12):8103-8117. doi: 10.1021/acs.jmedchem.3c00432. Epub 2023 Jun 12. J Med Chem. 2023. PMID: 37307241 Free PMC article.
Evaluation of Sequential Oral Versus Intravenous Antibiotic Treatment of Enterococcus faecalis Bloodstream Infections.
Loudermilk C, Eudy J, Albrecht S, Slaton CN, Stramel S, Tu P, Albrecht B, Green SB, Bouchard JL, Orvin AI, Caveness CF, Newsome AS, Bland CM, Anderson DT. Loudermilk C, et al. Among authors: bouchard jl. Ann Pharmacother. 2024 Jun 17:10600280241260146. doi: 10.1177/10600280241260146. Online ahead of print. Ann Pharmacother. 2024. PMID: 38887006
28 results