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Essential and virulence-related protein interactions of pathogens revealed through deep learning.
Humphreys IR, Zhang J, Baek M, Wang Y, Krishnakumar A, Pei J, Anishchenko I, Tower CA, Jackson BA, Warrier T, Hung DT, Peterson SB, Mougous JD, Cong Q, Baker D. Humphreys IR, et al. Among authors: hung dt. bioRxiv [Preprint]. 2024 Apr 12:2024.04.12.589144. doi: 10.1101/2024.04.12.589144. bioRxiv. 2024. Update in: Nat Microbiol. 2024 Oct;9(10):2642-2652. doi: 10.1038/s41564-024-01791-x PMID: 38645026 Free PMC article. Updated. Preprint.
"Multiplexed screen identifies a Pseudomonas aeruginosa -specific small molecule targeting the outer membrane protein OprH and its interaction with LPS".
Poulsen BE, Warrier T, Barkho S, Bagnall J, Romano KP, White T, Yu X, Kawate T, Nguyen PH, Raines K, Ferrara K, Golas A, Fitzgerald M, Boeszoermenyi A, Kaushik V, Serrano-Wu M, Shoresh N, Hung DT. Poulsen BE, et al. Among authors: hung dt. bioRxiv [Preprint]. 2024 Mar 16:2024.03.16.585348. doi: 10.1101/2024.03.16.585348. bioRxiv. 2024. Update in: Cell Chem Biol. 2024 Dec 26:S2451-9456(24)00490-2. doi: 10.1016/j.chembiol.2024.12.001 PMID: 38559044 Free PMC article. Updated. Preprint.
Massively parallel combination screen reveals small molecule sensitization of antibiotic-resistant Gram-negative ESKAPE pathogens.
Tse MW, Zhu M, Peters B, Hamami E, Chen J, Davis KP, Nitz S, Weller J, Warrier T, Hunt DK, Morales Y, Kawate T, Gaulin JL, Come JH, Hernandez-Bird J, Huo W, Neisewander I, Kiessling LL, Hung DT, Mecsas J, Aldridge BB, Isberg RR, Blainey PC. Tse MW, et al. Among authors: hung dt. bioRxiv [Preprint]. 2024 Mar 26:2024.03.26.586803. doi: 10.1101/2024.03.26.586803. bioRxiv. 2024. PMID: 38585790 Free PMC article. Preprint.
Discovery of a Pseudomonas aeruginosa-specific small molecule targeting outer membrane protein OprH-LPS interaction by a multiplexed screen.
Poulsen BE, Warrier T, Barkho S, Bagnall J, Romano KP, White T, Yu X, Kawate T, Nguyen PH, Raines K, Ferrara K, Golas AL, FitzGerald M, Boeszoermenyi A, Kaushik V, Serrano-Wu M, Shoresh N, Hung DT. Poulsen BE, et al. Among authors: hung dt. Cell Chem Biol. 2024 Dec 26:S2451-9456(24)00490-2. doi: 10.1016/j.chembiol.2024.12.001. Online ahead of print. Cell Chem Biol. 2024. PMID: 39732052
Corrigendum: Effectiveness of perindopril/amlodipine fixed-dose combination in the treatment of hypertension: a systematic review.
Dat TV, Tu VL, Thu LNA, Quang NNA, Binh V, Nga NTQ, Loc DH, Nguyen TTH, Tam DNH, Huynh HH, Trung TD, Do U, Phat NT, Hung DT, Nguyen QH, Yen NTH, Minh LHN. Dat TV, et al. Among authors: hung dt. Front Pharmacol. 2024 Oct 17;15:1485834. doi: 10.3389/fphar.2024.1485834. eCollection 2024. Front Pharmacol. 2024. PMID: 39484163 Free PMC article.
Author Correction: Pathogen genomic surveillance status among lower resource settings in Asia.
Getchell M, Wulandari S, de Alwis R, Agoramurthy S, Khoo YK, Mak TM, Moe L, Stona AC, Pang J, Momin MHFHA, Amir A, Andalucia LR, Azzam G, Chin S, Chookajorn T, Arunkumar G, Hung DT, Ikram A, Jha R, Karlsson EA, Le Thi MQ, Mahasirimongkol S, Malavige GN, Manning JE, Munira SL, Trung NV, Nisar I, Qadri F, Qamar FN, Robinson MT, Saloma CP, Setk S, Shirin T, Tan LV, Dizon TJR, Thayan R, Thu HM, Tissera H, Xangsayarath P, Zaini Z, Lim JCW, Maurer-Stroh S, Smith GJD, Wang LF, Pronyk P; Asia Pathogen Genomics Initiative (Asia PGI) consortium. Getchell M, et al. Among authors: hung dt. Nat Microbiol. 2025 Jan;10(1):258. doi: 10.1038/s41564-024-01848-x. Nat Microbiol. 2025. PMID: 39414934 No abstract available.
Evaluation of expanded 2-aminobenzothiazole library as inhibitors of a model histidine kinase and virulence suppressors in Pseudomonas aeruginosa.
Fihn CA, Lembke HK, Gaulin J, Bouchard P, Villarreal AR, Penningroth MR, Crone KK, Vogt GA, Gilbertsen AJ, Ayotte Y, Coutinho de Oliveira L, Serrano-Wu MH, Drouin N, Hung DT, Hunter RC, Carlson EE. Fihn CA, et al. Among authors: hung dt. Bioorg Chem. 2024 Dec;153:107840. doi: 10.1016/j.bioorg.2024.107840. Epub 2024 Sep 21. Bioorg Chem. 2024. PMID: 39362083
185 results