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Elucidating the anti-obesity potential of bioactive fractions of kalanchoe pinnata (lam.) leaves extract using a combination of in vitro, in vivo and in silico methods along with characterisation of lead compounds through an HPTLC ms-MSn analytical study.
Pratap Singh R, Pattnaik AK. Pratap Singh R, et al. Among authors: pattnaik ak. Nat Prod Res. 2024 Apr 24:1-6. doi: 10.1080/14786419.2024.2344183. Online ahead of print. Nat Prod Res. 2024. PMID: 38656916
A Series of Ferulic Acid Amides Reveals Unexpected Peroxiredoxin 1 Inhibitory Activity with in vivo Antidiabetic and Hypolipidemic Effects.
Yasmin S, Cerchia C, Badavath VN, Laghezza A, Dal Piaz F, Mondal SK, Atlı Ö, Baysal M, Vadivelan S, Shankar S, Siddique MUM, Pattnaik AK, Singh RP, Loiodice F, Jayaprakash V, Lavecchia A. Yasmin S, et al. Among authors: pattnaik ak. ChemMedChem. 2021 Feb 4;16(3):484-498. doi: 10.1002/cmdc.202000564. Epub 2020 Oct 29. ChemMedChem. 2021. PMID: 33030290
A chemical modification of a peroxisome proliferator-activated receptor pan agonist produced a shift to a new dual alpha/gamma partial agonist endowed with mitochondrial pyruvate carrier inhibition and antidiabetic properties.
Laghezza A, Cerchia C, Genovese M, Montanari R, Capelli D, Wackerlig J, Simic S, Falbo E, Pecora L, Leuci R, Brunetti L, Piemontese L, Tortorella P, Biswas A, Singh RP, Tambe S, Sudeep CA, Pattnaik AK, Jayaprakash V, Paoli P, Lavecchia A, Loiodice F. Laghezza A, et al. Among authors: pattnaik ak. Eur J Med Chem. 2024 Sep 5;275:116567. doi: 10.1016/j.ejmech.2024.116567. Epub 2024 Jun 9. Eur J Med Chem. 2024. PMID: 38865743
A New Antidiabetic Agent Showing Short- and Long-Term Effects Due to Peroxisome Proliferator-Activated Receptor Alpha/Gamma Dual Agonism and Mitochondrial Pyruvate Carrier Inhibition.
Laghezza A, Cerchia C, Genovese M, Leuci R, Pranzini E, Santi A, Brunetti L, Piemontese L, Tortorella P, Biswas A, Singh RP, Tambe S, Ca S, Pattnaik AK, Jayaprakash V, Paoli P, Lavecchia A, Loiodice F. Laghezza A, et al. Among authors: pattnaik ak. J Med Chem. 2023 Mar 9;66(5):3566-3587. doi: 10.1021/acs.jmedchem.2c02093. Epub 2023 Feb 15. J Med Chem. 2023. PMID: 36790935
Liquid Chromatography-Electrospray Ionization Tandem Mass Spectrometry Estimation of Quercetin-Loaded Nanoemulsion in Rabbit Plasma: In Vivo-In Silico Pharmacokinetic Analysis Using GastroPlus.
Das SS, Verma PRP, Sekarbabu V, Mohanty S, Pattnaik AK, Ruokolainen J, Kesari KK, Singh SK. Das SS, et al. Among authors: pattnaik ak. ACS Omega. 2023 Mar 20;8(13):12456-12466. doi: 10.1021/acsomega.3c00429. eCollection 2023 Apr 4. ACS Omega. 2023. PMID: 37033804 Free PMC article.
120 results