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Single-cell T cell receptor sequencing of paired human atherosclerotic plaques and blood reveals autoimmune-like features of expanded effector T cells.
Depuydt MAC, Schaftenaar FH, Prange KHM, Boltjes A, Hemme E, Delfos L, de Mol J, de Jong MJM, Bernabé Kleijn MNA, Peeters JAHM, Goncalves L, Wezel A, Smeets HJ, de Borst GJ, Foks AC, Pasterkamp G, de Winther MPJ, Kuiper J, Bot I, Slütter B. Depuydt MAC, et al. Among authors: prange khm. Nat Cardiovasc Res. 2023;2(2):112-125. doi: 10.1038/s44161-022-00208-4. Epub 2023 Jan 30. Nat Cardiovasc Res. 2023. PMID: 38665903 Free PMC article.
Myeloid Kdm6b deficiency results in advanced atherosclerosis.
Neele AE, Gijbels MJJ, van der Velden S, Hoeksema MA, Boshuizen MCS, Prange KHM, Chen HJ, Van den Bossche J, van Roomen CPPA, Shami A, Levels JHM, Kroon J, Lucas T, Dimmeler S, Lutgens E, de Winther MPJ. Neele AE, et al. Among authors: prange khm. Atherosclerosis. 2018 Aug;275:156-165. doi: 10.1016/j.atherosclerosis.2018.05.052. Epub 2018 Jun 1. Atherosclerosis. 2018. PMID: 29908485 Free article.
Peritoneal macrophages have an impaired immune response in obesity which can be reversed by subsequent weight loss.
Willemsen L, Neele AE, van der Velden S, Prange KHM, den Toom M, van Roomen CPAA, Reiche ME, Griffith GR, Gijbels MJJ, Lutgens E, de Winther MPJ. Willemsen L, et al. Among authors: prange khm. BMJ Open Diabetes Res Care. 2019 Nov 2;7(1):e000751. doi: 10.1136/bmjdrc-2019-000751. eCollection 2019. BMJ Open Diabetes Res Care. 2019. PMID: 31798899 Free PMC article.
Atherogenic Lipoprotein(a) Increases Vascular Glycolysis, Thereby Facilitating Inflammation and Leukocyte Extravasation.
Schnitzler JG, Hoogeveen RM, Ali L, Prange KHM, Waissi F, van Weeghel M, Bachmann JC, Versloot M, Borrelli MJ, Yeang C, De Kleijn DPV, Houtkooper RH, Koschinsky ML, de Winther MPJ, Groen AK, Witztum JL, Tsimikas S, Stroes ESG, Kroon J. Schnitzler JG, et al. Among authors: prange khm. Circ Res. 2020 May 8;126(10):1346-1359. doi: 10.1161/CIRCRESAHA.119.316206. Epub 2020 Mar 12. Circ Res. 2020. PMID: 32160811 Free PMC article.
Microanatomy of the Human Atherosclerotic Plaque by Single-Cell Transcriptomics.
Depuydt MAC, Prange KHM, Slenders L, Örd T, Elbersen D, Boltjes A, de Jager SCA, Asselbergs FW, de Borst GJ, Aavik E, Lönnberg T, Lutgens E, Glass CK, den Ruijter HM, Kaikkonen MU, Bot I, Slütter B, van der Laan SW, Yla-Herttuala S, Mokry M, Kuiper J, de Winther MPJ, Pasterkamp G. Depuydt MAC, et al. Among authors: prange khm. Circ Res. 2020 Nov 6;127(11):1437-1455. doi: 10.1161/CIRCRESAHA.120.316770. Epub 2020 Sep 28. Circ Res. 2020. PMID: 32981416 Free PMC article.
33 results