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Drug Repurposing of Histone Deacetylase Inhibitors That Alleviate Neutrophilic Inflammation in Acute Lung Injury and Idiopathic Pulmonary Fibrosis via Inhibiting Leukotriene A4 Hydrolase and Blocking LTB4 Biosynthesis.
Lu W, Yao X, Ouyang P, Dong N, Wu D, Jiang X, Wu Z, Zhang C, Xu Z, Tang Y, Zou S, Liu M, Li J, Zeng M, Lin P, Cheng F, Huang J. Lu W, et al. Among authors: zhang c. J Med Chem. 2017 Mar 9;60(5):1817-1828. doi: 10.1021/acs.jmedchem.6b01507. Epub 2017 Feb 28. J Med Chem. 2017. PMID: 28218840
Optimization of Chromeno[2,3- c]pyrrol-9(2 H)-ones as Highly Potent, Selective, and Orally Bioavailable PDE5 Inhibitors: Structure-Activity Relationship, X-ray Crystal Structure, and Pharmacodynamic Effect on Pulmonary Arterial Hypertension.
Wu D, Huang Y, Chen Y, Huang YY, Geng H, Zhang T, Zhang C, Li Z, Guo L, Chen J, Luo HB. Wu D, et al. Among authors: zhang c, zhang t. J Med Chem. 2018 Sep 27;61(18):8468-8473. doi: 10.1021/acs.jmedchem.8b01209. Epub 2018 Sep 7. J Med Chem. 2018. PMID: 30148362
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