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Type I IFN-mediated NET release promotes Mycobacterium tuberculosis replication and is associated with granuloma caseation.
Chowdhury CS, Kinsella RL, McNehlan ME, Naik SK, Lane DS, Talukdar P, Smirnov A, Dubey N, Rankin AN, McKee SR, Woodson R, Hii A, Chavez SM, Kreamalmeyer D, Beatty W, Mattila JT, Stallings CL. Chowdhury CS, et al. Among authors: mcnehlan me. Cell Host Microbe. 2024 Dec 11;32(12):2092-2111.e7. doi: 10.1016/j.chom.2024.11.008. Epub 2024 Dec 4. Cell Host Microbe. 2024. PMID: 39637864 Free article.
Autophagy promotes efficient T cell responses to restrict high-dose Mycobacterium tuberculosis infection in mice.
Feng S, McNehlan ME, Kinsella RL, Sur Chowdhury C, Chavez SM, Naik SK, McKee SR, Van Winkle JA, Dubey N, Samuels A, Swain A, Cui X, Hendrix SV, Woodson R, Kreamalmeyer D, Smirnov A, Artyomov MN, Virgin HW, Wang YT, Stallings CL. Feng S, et al. Among authors: mcnehlan me. Nat Microbiol. 2024 Mar;9(3):684-697. doi: 10.1038/s41564-024-01608-x. Epub 2024 Feb 27. Nat Microbiol. 2024. PMID: 38413834
Type I IFN signaling in the absence of IRGM1 promotes M. tuberculosis replication in immune cells by suppressing T cell responses.
Naik SK, McNehlan ME, Mreyoud Y, Kinsella RL, Smirnov A, Chowdhury CS, McKee SR, Dubey N, Woodson R, Kreamalmeyer D, Stallings CL. Naik SK, et al. Among authors: mcnehlan me. bioRxiv [Preprint]. 2023 Oct 5:2023.10.03.560720. doi: 10.1101/2023.10.03.560720. bioRxiv. 2023. Update in: Mucosal Immunol. 2024 Oct;17(5):1114-1127. doi: 10.1016/j.mucimm.2024.07.002 PMID: 37873329 Free PMC article. Updated. Preprint.