Uterine leiomyosarcomas harboring MAP2K4 gene amplification are sensitive in vivo to PLX8725, a novel MAP2K4 inhibitor.
McNamara B, Harold J, Manavella D, Bellone S, Mutlu L, Hartwich TMP, Zipponi M, Yang-Hartwich Y, Demirkiran C, Verzosa MSZ, Yang K, Choi J, Dong W, Buza N, Hui P, Altwerger G, Huang GS, Andikyan V, Clark M, Ratner E, Azodi M, Schwartz PE, Burton EA, Inagaki H, Albers A, Zhang C, Bollag G, Schlessinger J, Santin AD.
McNamara B, et al. Among authors: zhang c.
Gynecol Oncol. 2023 May;172:65-71. doi: 10.1016/j.ygyno.2023.03.009. Epub 2023 Mar 21.
Gynecol Oncol. 2023.
PMID: 36958197
Free PMC article.