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A CTCF-binding site in the Mdm1-Il22-Ifng locus shapes cytokine expression profiles and plays a critical role in early Th1 cell fate specification.
Liu C, Nagashima H, Fernando N, Bass V, Gopalakrishnan J, Signorella S, Montgomery W, Lim AI, Harrison O, Reich L, Yao C, Sun HW, Brooks SR, Jiang K, Nagarajan V, Zhao Y, Jung S, Phillips R, Mikami Y, Lareau CA, Kanno Y, Jankovic D, Aryee MJ, Pękowska A, Belkaid Y, O'Shea J, Shih HY. Liu C, et al. Among authors: nagashima h. Immunity. 2024 May 14;57(5):1005-1018.e7. doi: 10.1016/j.immuni.2024.04.007. Epub 2024 May 1. Immunity. 2024. PMID: 38697116
A PI3Kδ-Foxo1-FasL signaling amplification loop rewires CD4+ T helper cell signaling, differentiation and epigenetic remodeling.
Golec DP, Gazzinelli-Guimaraes P, Chauss D, Nagashima H, Yu K, Hill T, Nivelo L, Cannons JL, Perry J, Joshi I, Pereira N, Oliveira FMS, Cruz AC, Druey KM, Lack JB, Nutman TB, Villarino AV, O'Shea JJ, Afzali B, Schwartzberg PL. Golec DP, et al. Among authors: nagashima h. bioRxiv [Preprint]. 2024 Nov 2:2024.10.28.620691. doi: 10.1101/2024.10.28.620691. bioRxiv. 2024. PMID: 39803425 Free PMC article. Preprint.
A dual role of Cohesin in DNA DSB repair.
Fedkenheuer M, Shang Y, Jung S, Fedkenheuer K, Park S, Mazza D, Sebastian R, Nagashima H, Zong D, Tan H, Jaiswal SK, Fu H, Cruz A, Vartak SV, Wisniewski J, Sartorelli V, O'Shea JJ, Elnitski L, Nussenzweig A, Aladjem MI, Meng FL, Casellas R. Fedkenheuer M, et al. Among authors: nagashima h. Nat Commun. 2025 Jan 20;16(1):843. doi: 10.1038/s41467-025-56086-4. Nat Commun. 2025. PMID: 39833168 Free PMC article.
A step towards tackling chemotherapy-induced peripheral neuropathy (CIPN).
Maemondo M, Cho K, Saikawa H, Hashimoto T, Katagiri H, Owada Y, Yakuwa K, Fujimura I, Utsumi Y, Akiyama M, Nagashima H, Takahashi F. Maemondo M, et al. Among authors: nagashima h. Ann Palliat Med. 2024 Nov;13(6):1554-1555. doi: 10.21037/apm-24-113. Ann Palliat Med. 2024. PMID: 39632821 Free article. No abstract available.
Naturally arising memory-phenotype CD4+ T lymphocytes contain an undifferentiated population that can generate TH1, TH17, and Treg cells.
Kawajiri A, Li J, Koinuma K, Yang Z, Yoon HJ, Yi J, Nagashima H, Ishii M, Gao F, Sato K, Tayama S, Harigae H, Iwakura Y, Ishii N, Sher A, Ishigaki K, Zhu J, Kim KS, Kawabe T. Kawajiri A, et al. Among authors: nagashima h. Sci Adv. 2024 Dec 6;10(49):eadq6618. doi: 10.1126/sciadv.adq6618. Epub 2024 Dec 4. Sci Adv. 2024. PMID: 39630890 Free PMC article.
1,227 results