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204 results

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Page 1
Endogenous Formaldehyde Is a Hematopoietic Stem Cell Genotoxin and Metabolic Carcinogen.
Pontel LB, Rosado IV, Burgos-Barragan G, Garaycoechea JI, Yu R, Arends MJ, Chandrasekaran G, Broecker V, Wei W, Liu L, Swenberg JA, Crossan GP, Patel KJ. Pontel LB, et al. Among authors: arends mj. Mol Cell. 2015 Oct 1;60(1):177-88. doi: 10.1016/j.molcel.2015.08.020. Epub 2015 Sep 24. Mol Cell. 2015. PMID: 26412304 Free PMC article.
Aldehyde-driven transcriptional stress triggers an anorexic DNA damage response.
Mulderrig L, Garaycoechea JI, Tuong ZK, Millington CL, Dingler FA, Ferdinand JR, Gaul L, Tadross JA, Arends MJ, O'Rahilly S, Crossan GP, Clatworthy MR, Patel KJ. Mulderrig L, et al. Among authors: arends mj. Nature. 2021 Dec;600(7887):158-163. doi: 10.1038/s41586-021-04133-7. Epub 2021 Nov 24. Nature. 2021. PMID: 34819667
MEK1/2 inhibitor withdrawal reverses acquired resistance driven by BRAFV600E amplification whereas KRASG13D amplification promotes EMT-chemoresistance.
Sale MJ, Balmanno K, Saxena J, Ozono E, Wojdyla K, McIntyre RE, Gilley R, Woroniuk A, Howarth KD, Hughes G, Dry JR, Arends MJ, Caro P, Oxley D, Ashton S, Adams DJ, Saez-Rodriguez J, Smith PD, Cook SJ. Sale MJ, et al. Among authors: arends mj. Nat Commun. 2019 May 2;10(1):2030. doi: 10.1038/s41467-019-09438-w. Nat Commun. 2019. PMID: 31048689 Free PMC article.
MYC sensitises cells to apoptosis by driving energetic demand.
Edwards-Hicks J, Su H, Mangolini M, Yoneten KK, Wills J, Rodriguez-Blanco G, Young C, Cho K, Barker H, Muir M, Guerrieri AN, Li XF, White R, Manasterski P, Mandrou E, Wills K, Chen J, Abraham E, Sateri K, Qian BZ, Bankhead P, Arends M, Gammoh N, von Kriegsheim A, Patti GJ, Sims AH, Acosta JC, Brunton V, Kranc KR, Christophorou M, Pearce EL, Ringshausen I, Finch AJ. Edwards-Hicks J, et al. Nat Commun. 2022 Aug 9;13(1):4674. doi: 10.1038/s41467-022-32368-z. Nat Commun. 2022. PMID: 35945217 Free PMC article.
Reversible Myc hypomorphism identifies a key Myc-dependency in early cancer evolution.
Sodir NM, Pellegrinet L, Kortlever RM, Campos T, Kwon YW, Kim S, Garcia D, Perfetto A, Anastasiou P, Swigart LB, Arends MJ, Littlewood TD, Evan GI. Sodir NM, et al. Among authors: arends mj. Nat Commun. 2022 Nov 9;13(1):6782. doi: 10.1038/s41467-022-34079-x. Nat Commun. 2022. PMID: 36351945 Free PMC article.
Genetic determinants of micronucleus formation in vivo.
Adams DJ, Barlas B, McIntyre RE, Salguero I, van der Weyden L, Barros A, Vicente JR, Karimpour N, Haider A, Ranzani M, Turner G, Thompson NA, Harle V, Olvera-León R, Robles-Espinoza CD, Speak AO, Geisler N, Weninger WJ, Geyer SH, Hewinson J, Karp NA; Sanger Mouse Genetics Project; Fu B, Yang F, Kozik Z, Choudhary J, Yu L, van Ruiten MS, Rowland BD, Lelliott CJ, Del Castillo Velasco-Herrera M, Verstraten R, Bruckner L, Henssen AG, Rooimans MA, de Lange J, Mohun TJ, Arends MJ, Kentistou KA, Coelho PA, Zhao Y, Zecchini H, Perry JRB, Jackson SP, Balmus G. Adams DJ, et al. Among authors: arends mj. Nature. 2024 Mar;627(8002):130-136. doi: 10.1038/s41586-023-07009-0. Epub 2024 Feb 14. Nature. 2024. PMID: 38355793 Free PMC article.
204 results