Crossan GP - Search Results

1

Primordial germ cell DNA demethylation and development require DNA translesion synthesis.

Shah P, Hill R, Dion C, Clark SJ, Abakir A, Willems J, Arends MJ, Garaycoechea JI, Leitch HG, Reik W, Crossan GP. Shah P, et al. Among authors: crossan gp. Nat Commun. 2024 May 3;15(1):3734. doi: 10.1038/s41467-024-47219-2. Nat Commun. 2024. PMID: 38702312 Free PMC article.

2

p53 regulates diverse tissue-specific outcomes to endogenous DNA damage in mice.

Hill RJ, Bona N, Smink J, Webb HK, Crisp A, Garaycoechea JI, Crossan GP. Hill RJ, et al. Among authors: crossan gp. Nat Commun. 2024 Mar 21;15(1):2518. doi: 10.1038/s41467-024-46844-1. Nat Commun. 2024. PMID: 38514641 Free PMC article.

3

Fanconi anemia DNA crosslink repair factors protect against LINE-1 retrotransposition during mouse development.

Bona N, Crossan GP. Bona N, et al. Among authors: crossan gp. Nat Struct Mol Biol. 2023 Oct;30(10):1434-1445. doi: 10.1038/s41594-023-01067-8. Epub 2023 Aug 14. Nat Struct Mol Biol. 2023. PMID: 37580626 Free PMC article.

4

GCNA is a histone binding protein required for spermatogonial stem cell maintenance.

Ribeiro J, Crossan GP. Ribeiro J, et al. Among authors: crossan gp. Nucleic Acids Res. 2023 Jun 9;51(10):4791-4813. doi: 10.1093/nar/gkad168. Nucleic Acids Res. 2023. PMID: 36919611 Free PMC article.

5

Endogenous formaldehyde scavenges cellular glutathione resulting in redox disruption and cytotoxicity.

Umansky C, Morellato AE, Rieckher M, Scheidegger MA, Martinefski MR, Fernández GA, Pak O, Kolesnikova K, Reingruber H, Bollini M, Crossan GP, Sommer N, Monge ME, Schumacher B, Pontel LB. Umansky C, et al. Among authors: crossan gp. Nat Commun. 2022 Feb 8;13(1):745. doi: 10.1038/s41467-022-28242-7. Nat Commun. 2022. PMID: 35136057 Free PMC article.

6

Aldehyde-driven transcriptional stress triggers an anorexic DNA damage response.

Mulderrig L, Garaycoechea JI, Tuong ZK, Millington CL, Dingler FA, Ferdinand JR, Gaul L, Tadross JA, Arends MJ, O'Rahilly S, Crossan GP, Clatworthy MR, Patel KJ. Mulderrig L, et al. Among authors: crossan gp. Nature. 2021 Dec;600(7887):158-163. doi: 10.1038/s41586-021-04133-7. Epub 2021 Nov 24. Nature. 2021. PMID: 34819667

7

DNA cross-link repair safeguards genomic stability during premeiotic germ cell development.

Hill RJ, Crossan GP. Hill RJ, et al. Among authors: crossan gp. Nat Genet. 2019 Aug;51(8):1283-1294. doi: 10.1038/s41588-019-0471-2. Epub 2019 Jul 31. Nat Genet. 2019. PMID: 31367016 Free PMC article.

8

Alcohol and endogenous aldehydes damage chromosomes and mutate stem cells.

Garaycoechea JI, Crossan GP, Langevin F, Mulderrig L, Louzada S, Yang F, Guilbaud G, Park N, Roerink S, Nik-Zainal S, Stratton MR, Patel KJ. Garaycoechea JI, et al. Among authors: crossan gp. Nature. 2018 Jan 11;553(7687):171-177. doi: 10.1038/nature25154. Epub 2018 Jan 3. Nature. 2018. PMID: 29323295 Free PMC article.

9

Metformin: treating the cause of Fanconi anemia?

Crossan GP. Crossan GP. Blood. 2016 Dec 15;128(24):2748-2750. doi: 10.1182/blood-2016-11-748129. Blood. 2016. PMID: 27979864 Free PMC article.

10

Endogenous Formaldehyde Is a Hematopoietic Stem Cell Genotoxin and Metabolic Carcinogen.

Pontel LB, Rosado IV, Burgos-Barragan G, Garaycoechea JI, Yu R, Arends MJ, Chandrasekaran G, Broecker V, Wei W, Liu L, Swenberg JA, Crossan GP, Patel KJ. Pontel LB, et al. Among authors: crossan gp. Mol Cell. 2015 Oct 1;60(1):177-88. doi: 10.1016/j.molcel.2015.08.020. Epub 2015 Sep 24. Mol Cell. 2015. PMID: 26412304 Free PMC article.

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