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Epigenetic reprogramming enables the transition from primordial germ cell to gonocyte.
Hill PWS, Leitch HG, Requena CE, Sun Z, Amouroux R, Roman-Trufero M, Borkowska M, Terragni J, Vaisvila R, Linnett S, Bagci H, Dharmalingham G, Haberle V, Lenhard B, Zheng Y, Pradhan S, Hajkova P. Hill PWS, et al. Among authors: leitch hg. Nature. 2018 Mar 15;555(7696):392-396. doi: 10.1038/nature25964. Epub 2018 Mar 7. Nature. 2018. PMID: 29513657 Free PMC article.
Reconstitution of the oocyte transcriptional network with transcription factors.
Hamazaki N, Kyogoku H, Araki H, Miura F, Horikawa C, Hamada N, Shimamoto S, Hikabe O, Nakashima K, Kitajima TS, Ito T, Leitch HG, Hayashi K. Hamazaki N, et al. Among authors: leitch hg. Nature. 2021 Jan;589(7841):264-269. doi: 10.1038/s41586-020-3027-9. Epub 2020 Dec 16. Nature. 2021. PMID: 33328630
Determining the potency of primordial germ cells by injection into early mouse embryos.
Sepulveda-Rincon LP, Wang YF, Whilding C, Moyon B, Ojarikre OA, Maciulyte V, Hamazaki N, Hayashi K, Turner JMA, Leitch HG. Sepulveda-Rincon LP, et al. Among authors: leitch hg. Dev Cell. 2024 Mar 25;59(6):695-704.e5. doi: 10.1016/j.devcel.2024.01.022. Epub 2024 Feb 14. Dev Cell. 2024. PMID: 38359835 Free article.
The piRNA-pathway factor FKBP6 is essential for spermatogenesis but dispensable for control of meiotic LINE-1 expression in humans.
Wyrwoll MJ, Gaasbeek CM, Golubickaite I, Stakaitis R, Oud MS, Nagirnaja L, Dion C, Sindi EB, Leitch HG, Jayasena CN, Sironen A, Dicke AK, Rotte N, Stallmeyer B, Kliesch S, Grangeiro CHP, Araujo TF, Lasko P; Genetics of Male Infertility Initiative (GEMINI) consortium; D'Hauwers K, Smits RM, Ramos L, Xavier MJ, Conrad DF, Almstrup K, Veltman JA, Tüttelmann F, van der Heijden GW. Wyrwoll MJ, et al. Among authors: leitch hg. Am J Hum Genet. 2022 Oct 6;109(10):1850-1866. doi: 10.1016/j.ajhg.2022.09.002. Epub 2022 Sep 22. Am J Hum Genet. 2022. PMID: 36150389 Free PMC article.
Hallmarks of pluripotency.
De Los Angeles A, Ferrari F, Xi R, Fujiwara Y, Benvenisty N, Deng H, Hochedlinger K, Jaenisch R, Lee S, Leitch HG, Lensch MW, Lujan E, Pei D, Rossant J, Wernig M, Park PJ, Daley GQ. De Los Angeles A, et al. Among authors: leitch hg. Nature. 2015 Sep 24;525(7570):469-78. doi: 10.1038/nature15515. Nature. 2015. PMID: 26399828 Review.
Rebuilding pluripotency from primordial germ cells.
Leitch HG, Nichols J, Humphreys P, Mulas C, Martello G, Lee C, Jones K, Surani MA, Smith A. Leitch HG, et al. Stem Cell Reports. 2013 Jun 4;1(1):66-78. doi: 10.1016/j.stemcr.2013.03.004. eCollection 2013. Stem Cell Reports. 2013. PMID: 24052943 Free PMC article.
36 results