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Targeting CXCR4 impaired T regulatory function through PTEN in renal cancer patients.
Santagata S, Rea G, Bello AM, Capiluongo A, Napolitano M, Desicato S, Fragale A, D'Alterio C, Trotta AM, Ieranò C, Portella L, Persico F, Di Napoli M, Di Maro S, Feroce F, Azzaro R, Gabriele L, Longo N, Pignata S, Perdonà S, Scala S. Santagata S, et al. Br J Cancer. 2024 Jun;130(12):2016-2026. doi: 10.1038/s41416-024-02702-x. Epub 2024 May 4. Br J Cancer. 2024. PMID: 38704478 Free PMC article.
CXCR4 and CXCR7 transduce through mTOR in human renal cancer cells.
Ieranò C, Santagata S, Napolitano M, Guardia F, Grimaldi A, Antignani E, Botti G, Consales C, Riccio A, Nanayakkara M, Barone MV, Caraglia M, Scala S. Ieranò C, et al. Among authors: santagata s. Cell Death Dis. 2014 Jul 3;5(7):e1310. doi: 10.1038/cddis.2014.269. Cell Death Dis. 2014. PMID: 24991762 Free PMC article.
CXCR4-CXCL12-CXCR7, TLR2-TLR4, and PD-1/PD-L1 in colorectal cancer liver metastases from neoadjuvant-treated patients.
D'Alterio C, Nasti G, Polimeno M, Ottaiano A, Conson M, Circelli L, Botti G, Scognamiglio G, Santagata S, De Divitiis C, Nappi A, Napolitano M, Tatangelo F, Pacelli R, Izzo F, Vuttariello E, Botti G, Scala S. D'Alterio C, et al. Among authors: santagata s. Oncoimmunology. 2016 Nov 29;5(12):e1254313. doi: 10.1080/2162402X.2016.1254313. eCollection 2016. Oncoimmunology. 2016. PMID: 28123896 Free PMC article.
Targeting CXCR4 reverts the suppressive activity of T-regulatory cells in renal cancer.
Santagata S, Napolitano M, D'Alterio C, Desicato S, Maro SD, Marinelli L, Fragale A, Buoncervello M, Persico F, Gabriele L, Novellino E, Longo N, Pignata S, Perdonà S, Scala S. Santagata S, et al. Oncotarget. 2017 Aug 19;8(44):77110-77120. doi: 10.18632/oncotarget.20363. eCollection 2017 Sep 29. Oncotarget. 2017. PMID: 29100374 Free PMC article.
Mutated Von Hippel-Lindau-renal cell carcinoma (RCC) promotes patients specific natural killer (NK) cytotoxicity.
Trotta AM, Santagata S, Zanotta S, D'Alterio C, Napolitano M, Rea G, Camerlingo R, Esposito F, Lamantia E, Anniciello A, Botti G, Longo N, Botti G, Pignata S, Perdonà S, Scala S. Trotta AM, et al. Among authors: santagata s. J Exp Clin Cancer Res. 2018 Dec 4;37(1):297. doi: 10.1186/s13046-018-0952-7. J Exp Clin Cancer Res. 2018. PMID: 30514329 Free PMC article.
New CXCR4 Antagonist Peptide R (Pep R) Improves Standard Therapy in Colorectal Cancer.
D'Alterio C, Zannetti A, Trotta AM, Ieranò C, Napolitano M, Rea G, Greco A, Maiolino P, Albanese S, Scognamiglio G, Tatangelo F, Tafuto S, Portella L, Santagata S, Nasti G, Ottaiano A, Pacelli R, Delrio P, Botti G, Scala S. D'Alterio C, et al. Among authors: santagata s. Cancers (Basel). 2020 Jul 18;12(7):1952. doi: 10.3390/cancers12071952. Cancers (Basel). 2020. PMID: 32708431 Free PMC article.
Novel Peptide-Based PET Probe for Non-invasive Imaging of C-X-C Chemokine Receptor Type 4 (CXCR4) in Tumors.
Trotta AM, Aurilio M, D'Alterio C, Ieranò C, Di Martino D, Barbieri A, Luciano A, Gaballo P, Santagata S, Portella L, Tomassi S, Marinelli L, Sementa D, Novellino E, Lastoria S, Scala S, Schottelius M, Di Maro S. Trotta AM, et al. Among authors: santagata s. J Med Chem. 2021 Mar 25;64(6):3449-3461. doi: 10.1021/acs.jmedchem.1c00066. Epub 2021 Mar 4. J Med Chem. 2021. PMID: 33660512
Prospective Evaluation of Radiotherapy-Induced Immunologic and Genetic Effects in Colorectal Cancer Oligo-Metastatic Patients with Lung-Limited Disease: The PRELUDE-1 Study.
Ottaiano A, Petito A, Santorsola M, Gigantino V, Capuozzo M, Fontanella D, Di Franco R, Borzillo V, Buonopane S, Ravo V, Scipilliti E, Totaro G, Serra M, Ametrano G, Penta R, Tatangelo F, Scognamiglio G, Di Mauro A, Di Bonito M, Napolitano M, Scala S, Rea G, Santagata S, Lombardi A, Grimaldi A, Caputo C, Crispo A, Celentano E, De Feo G, Circelli L, Savarese G, Ruggiero R, Perri F, Granata V, Botti G, Caraglia M, Nasti G, Muto P. Ottaiano A, et al. Among authors: santagata s. Cancers (Basel). 2021 Aug 23;13(16):4236. doi: 10.3390/cancers13164236. Cancers (Basel). 2021. PMID: 34439390 Free PMC article.
280 results