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Seralutinib in adults with pulmonary arterial hypertension (TORREY): a randomised, double-blind, placebo-controlled phase 2 trial.
Frantz RP, McLaughlin VV, Sahay S, Escribano Subías P, Zolty RL, Benza RL, Channick RN, Chin KM, Hemnes AR, Howard LS, Sitbon O, Vachiéry JL, Zamanian RT, Cravets M, Roscigno RF, Mottola D, Osterhout R, Bruey JM, Elman E, Tompkins CA, Parsley E, Aranda R, Zisman LS, Ghofrani HA; TORREY Study Investigators. Frantz RP, et al. Among authors: zisman ls. Lancet Respir Med. 2024 Jul;12(7):523-534. doi: 10.1016/S2213-2600(24)00072-9. Epub 2024 May 2. Lancet Respir Med. 2024. PMID: 38705167 Clinical Trial.
Inhaled seralutinib exhibits potent efficacy in models of pulmonary arterial hypertension.
Galkin A, Sitapara R, Clemons B, Garcia E, Kennedy M, Guimond D, Carter LL, Douthitt A, Osterhout R, Gandjeva A, Slee D, Salter-Cid L, Tuder RM, Zisman LS. Galkin A, et al. Among authors: zisman ls. Eur Respir J. 2022 Dec 1;60(6):2102356. doi: 10.1183/13993003.02356-2021. Print 2022 Dec. Eur Respir J. 2022. PMID: 35680144 Free PMC article.
TORREY, a Phase 2 study to evaluate the efficacy and safety of inhaled seralutinib for the treatment of pulmonary arterial hypertension.
Frantz RP, Benza RL, Channick RN, Chin K, Howard LS, McLaughlin VV, Sitbon O, Zamanian RT, Hemnes AR, Cravets M, Bruey JM, Roscigno R, Mottola D, Elman E, Zisman LS, Ghofrani HA. Frantz RP, et al. Among authors: zisman ls. Pulm Circ. 2021 Nov 11;11(4):20458940211057071. doi: 10.1177/20458940211057071. eCollection 2021 Oct-Dec. Pulm Circ. 2021. PMID: 34790348 Free PMC article.
Dynamic Regulation of SARS-Cov-2 Binding and Cell Entry Mechanisms in Remodeled Human Ventricular Myocardium.
Bristow MR, Zisman LS, Altman NL, Gilbert EM, Lowes BD, Minobe WA, Slavov D, Schwisow JA, Rodriguez EM, Carroll IA, Keuer TA, Buttrick PM, Kao DP. Bristow MR, et al. Among authors: zisman ls. JACC Basic Transl Sci. 2020 Sep;5(9):871-883. doi: 10.1016/j.jacbts.2020.06.007. Epub 2020 Jun 24. JACC Basic Transl Sci. 2020. PMID: 32838074 Free PMC article.
31 results