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GPATCH8 modulates mutant SF3B1 mis-splicing and pathogenicity in hematologic malignancies.
Benbarche S, Pineda JMB, Galvis LB, Biswas J, Liu B, Wang E, Zhang Q, Hogg SJ, Lyttle K, Dahi A, Lewis AM, Sarchi M, Rahman J, Fox N, Ai Y, Mehta S, Garippa R, Ortiz-Pacheco J, Li Z, Monetti M, Stanley RF, Doulatov S, Bradley RK, Abdel-Wahab O. Benbarche S, et al. Mol Cell. 2024 May 16;84(10):1886-1903.e10. doi: 10.1016/j.molcel.2024.04.006. Epub 2024 Apr 29. Mol Cell. 2024. PMID: 38688280 Free article.
SRSF2 plays an unexpected role as reader of m5C on mRNA, linking epitranscriptomics to cancer.
Ma HL, Bizet M, Soares Da Costa C, Murisier F, de Bony EJ, Wang MK, Yoshimi A, Lin KT, Riching KM, Wang X, Beckman JI, Arya S, Droin N, Calonne E, Hassabi B, Zhang QY, Li A, Putmans P, Malbec L, Hubert C, Lan J, Mies F, Yang Y, Solary E, Daniels DL, Gupta YK, Deplus R, Abdel-Wahab O, Yang YG, Fuks F. Ma HL, et al. Mol Cell. 2023 Dec 7;83(23):4239-4254.e10. doi: 10.1016/j.molcel.2023.11.003. Mol Cell. 2023. PMID: 38065062 Free PMC article.
Disruption of cotranscriptional splicing suggests RBM39 is a therapeutic target in acute lymphoblastic leukemia.
Jin Q, Harris E, Myers JA, Mehmood R, Cotton A, Shirnekhi HK, Baggett DW, Wen JQ, Schild AB, Bhansali RS, Klein J, Narina S, Pieters T, Yoshimi A, Pruett-Miller SM, Kriwacki R, Abdel-Wahab O, Malinge S, Ntziachristos P, Obeng EA, Crispino JD. Jin Q, et al. Among authors: abdel wahab o. Blood. 2024 Dec 5;144(23):2417-2431. doi: 10.1182/blood.2024024281. Blood. 2024. PMID: 39316649 Free PMC article.
Splicing regulation of DNA repair via CCAR1.
Ai Y, Abdel-Wahab O. Ai Y, et al. Among authors: abdel wahab o. Mol Cell. 2024 Jul 25;84(14):2591-2592. doi: 10.1016/j.molcel.2024.06.012. Mol Cell. 2024. PMID: 39059366
Targeting the cBAF complex in T-ALL.
Chen B, Abdel-Wahab O. Chen B, et al. Blood. 2024 Feb 15;143(7):566-567. doi: 10.1182/blood.2023023040. Blood. 2024. PMID: 38358848 No abstract available.
361 results