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Increased levels of GM-CSF and CXCL10 and low CD8+ memory stem T Cell count are markers of immunosenescence and severe COVID-19 in older people.
Poisson J, El-Sissy C, Serret-Larmande A, Smith N, Lebraud M, Augy JL, Conti C, Gonnin C, Planquette B, Arlet JB, Hermann B, Charbit B, Pastre J, Devaux F, Ladavière C, Lim L, Ober P, Cannovas J, Biard L, Gulczynski MC, Blumenthal N, Péré H, Knosp C, Gey A, Benhamouda N, Murris J, Veyer D, Tartour E, Diehl JL, Duffy D, Paillaud E, Granier C. Poisson J, et al. Among authors: tartour e. Immun Ageing. 2024 May 7;21(1):28. doi: 10.1186/s12979-024-00430-7. Immun Ageing. 2024. PMID: 38715114 Free PMC article.
Distinctive roles of age, sex, and genetics in shaping transcriptional variation of human immune responses to microbial challenges.
Piasecka B, Duffy D, Urrutia A, Quach H, Patin E, Posseme C, Bergstedt J, Charbit B, Rouilly V, MacPherson CR, Hasan M, Albaud B, Gentien D, Fellay J, Albert ML, Quintana-Murci L; Milieu Intérieur Consortium. Piasecka B, et al. Proc Natl Acad Sci U S A. 2018 Jan 16;115(3):E488-E497. doi: 10.1073/pnas.1714765115. Epub 2017 Dec 27. Proc Natl Acad Sci U S A. 2018. PMID: 29282317 Free PMC article.
Functional analysis via standardized whole-blood stimulation systems defines the boundaries of a healthy immune response to complex stimuli.
Duffy D, Rouilly V, Libri V, Hasan M, Beitz B, David M, Urrutia A, Bisiaux A, Labrie ST, Dubois A, Boneca IG, Delval C, Thomas S, Rogge L, Schmolz M, Quintana-Murci L, Albert ML; Milieu Intérieur Consortium. Duffy D, et al. Immunity. 2014 Mar 20;40(3):436-50. doi: 10.1016/j.immuni.2014.03.002. Immunity. 2014. PMID: 24656047 Free article.
Human genetic variants and age are the strongest predictors of humoral immune responses to common pathogens and vaccines.
Scepanovic P, Alanio C, Hammer C, Hodel F, Bergstedt J, Patin E, Thorball CW, Chaturvedi N, Charbit B, Abel L, Quintana-Murci L, Duffy D, Albert ML, Fellay J; Milieu Intérieur Consortium. Scepanovic P, et al. Genome Med. 2018 Jul 27;10(1):59. doi: 10.1186/s13073-018-0568-8. Genome Med. 2018. PMID: 30053915 Free PMC article. Clinical Trial.
Parallel derivation of isogenic human primed and naive induced pluripotent stem cells.
Kilens S, Meistermann D, Moreno D, Chariau C, Gaignerie A, Reignier A, Lelièvre Y, Casanova M, Vallot C, Nedellec S, Flippe L, Firmin J, Song J, Charpentier E, Lammers J, Donnart A, Marec N, Deb W, Bihouée A, Le Caignec C, Pecqueur C, Redon R, Barrière P, Bourdon J, Pasque V, Soumillon M, Mikkelsen TS, Rougeulle C, Fréour T, David L; Milieu Intérieur Consortium. Kilens S, et al. Nat Commun. 2018 Jan 24;9(1):360. doi: 10.1038/s41467-017-02107-w. Nat Commun. 2018. PMID: 29367672 Free PMC article.
Natural variation in the parameters of innate immune cells is preferentially driven by genetic factors.
Patin E, Hasan M, Bergstedt J, Rouilly V, Libri V, Urrutia A, Alanio C, Scepanovic P, Hammer C, Jönsson F, Beitz B, Quach H, Lim YW, Hunkapiller J, Zepeda M, Green C, Piasecka B, Leloup C, Rogge L, Huetz F, Peguillet I, Lantz O, Fontes M, Di Santo JP, Thomas S, Fellay J, Duffy D, Quintana-Murci L, Albert ML; Milieu Intérieur Consortium. Patin E, et al. Nat Immunol. 2018 Mar;19(3):302-314. doi: 10.1038/s41590-018-0049-7. Epub 2018 Feb 23. Nat Immunol. 2018. PMID: 29476184 Free article.
Beta-variant recombinant SARS CoV-2 vaccine induces durable cross-reactive antibodies against Omicron BA variants.
Launay O, Gupta R, Machabert T, Konate E, Rousseau A, Vigne C, Beckers F, Devlin L, Botelho-Nevers E, Cachanado M, Chidiac C, Deplanque D, Dussol B, Ben Ghezala I, Lachatre M, Lacombe K, Laine F, Luong Nguyen LB, Pavese P, Schmidt-Mutter C, Tavolacci MP, Chicz RM, Coudsy B, Sridhar S, Touati A, Tartour E, Simon T. Launay O, et al. Among authors: tartour e. Commun Med (Lond). 2025 Jan 18;5(1):21. doi: 10.1038/s43856-024-00675-9. Commun Med (Lond). 2025. PMID: 39827332 Free PMC article.
CD57+ EMRA CD8+ T cells in cancer patients over 70: associations with prior chemotherapy and response to anti-PD-1/PD-L1 therapy.
Gonnin C, Leemans M, Canoui-Poitrine F, Lebraud M, Corneau A, Roquebert L, Caillet P, Gay P, Canovas J, Histe A, Blanc C, El-Sissy C, Larbi A, Poisson J, Ober P, Boudou-Rouquette P, Natella PA, Vallet H, Saadaoui B, Layese R, Tartour E, Paillaud E, Granier C. Gonnin C, et al. Among authors: tartour e. Immun Ageing. 2024 Dec 27;21(1):89. doi: 10.1186/s12979-024-00487-4. Immun Ageing. 2024. PMID: 39731117 Free PMC article.
315 results