McGowan S - Search Results

1

On-target, dual aminopeptidase inhibition provides cross-species antimalarial activity.

Edgar RCS, Malcolm TR, Siddiqui G, Giannangelo C, Counihan NA, Challis M, Duffy S, Chowdhury M, Marfurt J, Dans M, Wirjanata G, Noviyanti R, Daware K, Suraweera CD, Price RN, Wittlin S, Avery VM, Drinkwater N, Charman SA, Creek DJ, de Koning-Ward TF, Scammells PJ, McGowan S. Edgar RCS, et al. Among authors: mcgowan s. mBio. 2024 Jun 12;15(6):e0096624. doi: 10.1128/mbio.00966-24. Epub 2024 May 8. mBio. 2024. PMID: 38717141 Free PMC article.

2

Synthesis and structure-activity relationships of phosphonic arginine mimetics as inhibitors of the M1 and M17 aminopeptidases from Plasmodium falciparum.

Kannan Sivaraman K, Paiardini A, Sieńczyk M, Ruggeri C, Oellig CA, Dalton JP, Scammells PJ, Drag M, McGowan S. Kannan Sivaraman K, et al. Among authors: mcgowan s. J Med Chem. 2013 Jun 27;56(12):5213-7. doi: 10.1021/jm4005972. Epub 2013 Jun 13. J Med Chem. 2013. PMID: 23713488 Free article.

3

From crystal to compound: structure-based antimalarial drug discovery.

Drinkwater N, McGowan S. Drinkwater N, et al. Among authors: mcgowan s. Biochem J. 2014 Aug 1;461(3):349-69. doi: 10.1042/BJ20140240. Biochem J. 2014. PMID: 25008945 Review.

4

Two-pronged attack: dual inhibition of Plasmodium falciparum M1 and M17 metalloaminopeptidases by a novel series of hydroxamic acid-based inhibitors.

Mistry SN, Drinkwater N, Ruggeri C, Sivaraman KK, Loganathan S, Fletcher S, Drag M, Paiardini A, Avery VM, Scammells PJ, McGowan S. Mistry SN, et al. Among authors: mcgowan s. J Med Chem. 2014 Nov 13;57(21):9168-83. doi: 10.1021/jm501323a. Epub 2014 Oct 24. J Med Chem. 2014. PMID: 25299353

5

Structure and dynamics of apical membrane antigen 1 from Plasmodium falciparum FVO.

Lim SS, Yang W, Krishnarjuna B, Kannan Sivaraman K, Chandrashekaran IR, Kass I, MacRaild CA, Devine SM, Debono CO, Anders RF, Scanlon MJ, Scammells PJ, Norton RS, McGowan S. Lim SS, et al. Among authors: mcgowan s. Biochemistry. 2014 Nov 25;53(46):7310-20. doi: 10.1021/bi5012089. Epub 2014 Nov 14. Biochemistry. 2014. PMID: 25360546

6

X-ray crystal structures of an orally available aminopeptidase inhibitor, Tosedostat, bound to anti-malarial drug targets PfA-M1 and PfA-M17.

Drinkwater N, Bamert RS, Sivaraman KK, Paiardini A, McGowan S. Drinkwater N, et al. Among authors: mcgowan s. Proteins. 2015 Apr;83(4):789-95. doi: 10.1002/prot.24771. Epub 2015 Feb 28. Proteins. 2015. PMID: 25645579

7

Screening the Medicines for Malaria Venture "Malaria Box" against the Plasmodium falciparum aminopeptidases, M1, M17 and M18.

Paiardini A, Bamert RS, Kannan-Sivaraman K, Drinkwater N, Mistry SN, Scammells PJ, McGowan S. Paiardini A, et al. Among authors: mcgowan s. PLoS One. 2015 Feb 20;10(2):e0115859. doi: 10.1371/journal.pone.0115859. eCollection 2015. PLoS One. 2015. PMID: 25700165 Free PMC article.

8

Structural basis for epitope masking and strain specificity of a conserved epitope in an intrinsically disordered malaria vaccine candidate.

Morales RAV, MacRaild CA, Seow J, Krishnarjuna B, Drinkwater N, Rouet R, Anders RF, Christ D, McGowan S, Norton RS. Morales RAV, et al. Among authors: mcgowan s. Sci Rep. 2015 May 12;5:10103. doi: 10.1038/srep10103. Sci Rep. 2015. PMID: 25965408 Free PMC article.

9

Identification and Validation of a Potent Dual Inhibitor of the P. falciparum M1 and M17 Aminopeptidases Using Virtual Screening.

Ruggeri C, Drinkwater N, Sivaraman KK, Bamert RS, McGowan S, Paiardini A. Ruggeri C, et al. Among authors: mcgowan s. PLoS One. 2015 Sep 25;10(9):e0138957. doi: 10.1371/journal.pone.0138957. eCollection 2015. PLoS One. 2015. PMID: 26406322 Free PMC article.

10

Potent dual inhibitors of Plasmodium falciparum M1 and M17 aminopeptidases through optimization of S1 pocket interactions.

Drinkwater N, Vinh NB, Mistry SN, Bamert RS, Ruggeri C, Holleran JP, Loganathan S, Paiardini A, Charman SA, Powell AK, Avery VM, McGowan S, Scammells PJ. Drinkwater N, et al. Among authors: mcgowan s. Eur J Med Chem. 2016 Mar 3;110:43-64. doi: 10.1016/j.ejmech.2016.01.015. Epub 2016 Jan 13. Eur J Med Chem. 2016. PMID: 26807544

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