Keller MP - Search Results

1

Discovery of the Clinical Candidate IDOR-1117-2520: A Potent and Selective Antagonist of CCR6 for Autoimmune Diseases.

Meyer EA, Croxford AL, Gnerre C, Kulig P, Murphy MJ, Jacob EM, Schäfer G, Richard-Bildstein S, Aissaoui H, Bouis P, Ertel EA, de Kanter R, Keller MP, Lüthi U, Caroff E. Meyer EA, et al. Among authors: keller mp. J Med Chem. 2024 May 23;67(10):8077-8098. doi: 10.1021/acs.jmedchem.4c00186. Epub 2024 May 10. J Med Chem. 2024. PMID: 38727100

2

Preclinical to clinical translation of cenerimod, a novel S1P₁ receptor modulator, in systemic lupus erythematosus.

Strasser DS, Froidevaux S, Sippel V, Gerossier E, Grieder U, Pierlot GM, Kieninger-Graefitsch A, Vezzali E, Stalder AK, Renault B, Ryge J, Hart A, Mentzel U, Groenen PMA, Keller MP, Trendelenburg M, Martinic MM, Murphy MJ. Strasser DS, et al. Among authors: keller mp. RMD Open. 2020 Sep;6(2):e001261. doi: 10.1136/rmdopen-2020-001261. RMD Open. 2020. PMID: 32917831 Free PMC article.

3

In Vitro Characterization of Sphingosine 1-Phosphate Receptor 1 (S1P₁) Expression and Mediated Migration of Primary Human T and B Cells in the Context of Cenerimod, a Novel, Selective S1P₁ Receptor Modulator.

Schlicher L, Kulig P, von Münchow A, Murphy MJ, Keller MP. Schlicher L, et al. Among authors: keller mp. Int J Mol Sci. 2022 Jan 21;23(3):1191. doi: 10.3390/ijms23031191. Int J Mol Sci. 2022. PMID: 35163112 Free PMC article.

4

Discovery and In Vivo Evaluation of ACT-660602: A Potent and Selective Antagonist of the Chemokine Receptor CXCR3 for Autoimmune Diseases.

Meyer EA, Äänismaa P, Froidevaux S, Keller M, Piali L, Caroff E. Meyer EA, et al. J Med Chem. 2022 Sep 8;65(17):11513-11532. doi: 10.1021/acs.jmedchem.2c00675. Epub 2022 Aug 10. J Med Chem. 2022. PMID: 35947786

5

Design, Synthesis, and Pharmacological Evaluation of Benzimidazolo-thiazoles as Potent CXCR3 Antagonists with Therapeutic Potential in Autoimmune Diseases: Discovery of ACT-672125.

Caroff E, Meyer EA, Äänismaa P, Froidevaux S, Keller M, Piali L. Caroff E, et al. J Med Chem. 2022 Sep 8;65(17):11533-11549. doi: 10.1021/acs.jmedchem.2c00676. Epub 2022 Aug 15. J Med Chem. 2022. PMID: 35969159

6

Discovery of Clinical Candidate ACT-777991, a Potent CXCR3 Antagonist for Antigen-Driven and Inflammatory Pathologies.

Meyer EA, Äänismaa P, Ertel EA, Hühn E, Strasser DS, Rey M, Murphy MJ, Martinic MM, Pouzol L, Froidevaux S, Keller MP, Caroff E. Meyer EA, et al. Among authors: keller mp. J Med Chem. 2023 Mar 23;66(6):4179-4196. doi: 10.1021/acs.jmedchem.3c00074. Epub 2023 Mar 8. J Med Chem. 2023. PMID: 36883854

7

Pharmacodynamics of the S1P₁ receptor modulator cenerimod in a phase 2b randomised clinical trial in patients with moderate to severe SLE.

Suffiotti M, Brazauskas P, Keller MP, Berkani O, Seifer G, Cornelisse P, Murphy MJ, Strasser DS. Suffiotti M, et al. Among authors: keller mp. Ann Rheum Dis. 2024 Nov 24:ard-2024-226547. doi: 10.1136/ard-2024-226547. Online ahead of print. Ann Rheum Dis. 2024. PMID: 39581631 Free article.

8

Immunoaffinity Targeted Mass Spectrometry Analysis of Human Plasma Samples Reveals an Imbalance of Active and Inactive CXCL10 in Primary Sjögren's Syndrome Disease Patients.

Schmidt A, Farine H, Keller MP, Sebastian A, Kozera L, Welford RWD, Strasser DS. Schmidt A, et al. Among authors: keller mp. J Proteome Res. 2020 Oct 2;19(10):4196-4209. doi: 10.1021/acs.jproteome.0c00494. Epub 2020 Sep 15. J Proteome Res. 2020. PMID: 32870689

9

Transcripts with high distal heritability mediate genetic effects on complex metabolic traits.

Tyler AL, Mahoney JM, Keller MP, Baker CN, Gaca M, Srivastava A, Gerdes Gyuricza I, Braun MJ, Rosenthal NA, Attie AD, Churchill GA, Carter GW. Tyler AL, et al. Among authors: keller mp. bioRxiv [Preprint]. 2024 Sep 27:2024.09.26.613931. doi: 10.1101/2024.09.26.613931. bioRxiv. 2024. PMID: 39386475 Free PMC article. Preprint.

10

Multiple promoter and enhancer differences likely contribute to augmented G6PC2 expression in human versus mouse pancreatic islet alpha cells.

Martin CC, Oeser JK, Wangmo T, Flemming BP, Attie AD, Keller MP, O'Brien RM. Martin CC, et al. Among authors: keller mp. J Mol Endocrinol. 2024 Sep 18;73(3):e240051. doi: 10.1530/JME-24-0051. Print 2024 Oct 1. J Mol Endocrinol. 2024. PMID: 39121091

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