Placzek WJ - Search Results

1

l-2-Hydroxyglutarate remodeling of the epigenome and epitranscriptome creates a metabolic vulnerability in kidney cancer models.

Kundu A, Brinkley GJ, Nam H, Karki S, Kirkman R, Pandit M, Shim E, Widden H, Liu J, Heidarian Y, Mahmoudzadeh NH, Fitt AJ, Absher D, Ding HF, Crossman DK, Placzek WJ, Locasale JW, Rakheja D, McConathy JE, Ramachandran R, Bae S, Tennessen JM, Sudarshan S. Kundu A, et al. Among authors: placzek wj. J Clin Invest. 2024 May 14;134(13):e171294. doi: 10.1172/JCI171294. J Clin Invest. 2024. PMID: 38743486 Free PMC article.

2

Myeloid Cell Leukemia 1 Small Molecule Inhibitor S63845 Synergizes with Cisplatin in Triple-Negative Breast Cancer.

Acton A, Placzek WJ. Acton A, et al. Among authors: placzek wj. Cancers (Basel). 2023 Sep 8;15(18):4481. doi: 10.3390/cancers15184481. Cancers (Basel). 2023. PMID: 37760451 Free PMC article.

3

Reviewing PTBP1 Domain Modularity in the Pre-Genomic Era: A Foundation to Guide the Next Generation of Exploring PTBP1 Structure-Function Relationships.

Carico C, Placzek WJ. Carico C, et al. Among authors: placzek wj. Int J Mol Sci. 2023 Jul 7;24(13):11218. doi: 10.3390/ijms241311218. Int J Mol Sci. 2023. PMID: 37446395 Free PMC article. Review.

4

Polypyrimidine tract binding protein 1 (PTBP1) contains a novel regulatory sequence, the rBH3, that binds the prosurvival protein MCL1.

Carico C, Cui J, Acton A, Placzek WJ. Carico C, et al. Among authors: placzek wj. J Biol Chem. 2023 Jun;299(6):104778. doi: 10.1016/j.jbc.2023.104778. Epub 2023 May 3. J Biol Chem. 2023. PMID: 37142223 Free PMC article.

5

Phylogenetic analysis of the MCL1 BH3 binding groove and rBH3 sequence motifs in the p53 and INK4 protein families.

McGriff A, Placzek WJ. McGriff A, et al. Among authors: placzek wj. PLoS One. 2023 Jan 25;18(1):e0277726. doi: 10.1371/journal.pone.0277726. eCollection 2023. PLoS One. 2023. PMID: 36696417 Free PMC article.

6

The multiple mechanisms of MCL1 in the regulation of cell fate.

Widden H, Placzek WJ. Widden H, et al. Among authors: placzek wj. Commun Biol. 2021 Sep 2;4(1):1029. doi: 10.1038/s42003-021-02564-6. Commun Biol. 2021. PMID: 34475520 Free PMC article. Review.

7

MCL1 binds and negatively regulates the transcriptional function of tumor suppressor p73.

Widden H, Kaczmarczyk A, Subedi A, Whitaker RH, Placzek WJ. Widden H, et al. Among authors: placzek wj. Cell Death Dis. 2020 Nov 3;11(11):946. doi: 10.1038/s41419-020-03068-7. Cell Death Dis. 2020. PMID: 33144577 Free PMC article.

8

A cell-penetrating MARCKS mimetic selectively triggers cytolytic death in glioblastoma.

Eustace NJ, Anderson JC, Warram JM, Widden HN, Pedersen RT, Alrefai H, Patel Z, Hicks PH, Placzek WJ, Gillespie GY, Hjelmeland AB, Willey CD. Eustace NJ, et al. Among authors: placzek wj. Oncogene. 2020 Nov;39(46):6961-6974. doi: 10.1038/s41388-020-01511-9. Epub 2020 Oct 19. Oncogene. 2020. PMID: 33077834 Free PMC article.

9

The GTPase Rab27b regulates the release, autophagic clearance, and toxicity of α-synuclein.

Underwood R, Wang B, Carico C, Whitaker RH, Placzek WJ, Yacoubian TA. Underwood R, et al. Among authors: placzek wj. J Biol Chem. 2020 Jun 5;295(23):8005-8016. doi: 10.1074/jbc.RA120.013337. Epub 2020 Apr 29. J Biol Chem. 2020. PMID: 32350025 Free PMC article.

10

MCL1 binding to the reverse BH3 motif of P18INK4C couples cell survival to cell proliferation.

Whitaker RH, Placzek WJ. Whitaker RH, et al. Among authors: placzek wj. Cell Death Dis. 2020 Feb 28;11(2):156. doi: 10.1038/s41419-020-2351-1. Cell Death Dis. 2020. PMID: 32111816 Free PMC article.

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