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Page 1
Mechanistic safety assessment via multi-omic characterisation of systemic pathway perturbations following in vivo MAT2A inhibition.
Fogal V, Michopoulos F, Jarnuczak AF, Hamza GM, Harlfinger S, Davey P, Hulme H, Atkinson SJ, Gabrowski P, Cheung T, Grondine M, Hoover C, Rose J, Bray C, Foster AJ, Askin S, Majumder MM, Fitzpatrick P, Miele E, Macdonald R, Keun HC, Coen M. Fogal V, et al. Among authors: hoover c. Arch Toxicol. 2024 Aug;98(8):2589-2603. doi: 10.1007/s00204-024-03771-w. Epub 2024 May 17. Arch Toxicol. 2024. PMID: 38755480 Free PMC article.
Novel Arginase Inhibitor, AZD0011, Demonstrates Immune Cell Stimulation and Antitumor Efficacy with Diverse Combination Partners.
Doshi AS, Cantin S, Hernandez M, Srinivasan S, Tentarelli S, Griffin M, Wang Y, Pop-Damkov P, Prickett LB, Kankkonen C, Shen M, Martin MS, Wu S, Castaldi MP, Ghadially H, Varnes J, Gales S, Henry D, Hoover C, Mele DA, Simpson I, Gangl ET, Mlynarski SN, Finlay MRV, Drew L, Fawell SE, Shao W, Schuller AG. Doshi AS, et al. Among authors: hoover c. Mol Cancer Ther. 2023 May 4;22(5):630-645. doi: 10.1158/1535-7163.MCT-22-0431. Mol Cancer Ther. 2023. PMID: 36912782
Antitumor activity of AZD0754, a dnTGFβRII-armored, STEAP2-targeted CAR-T cell therapy, in prostate cancer.
Zanvit P, van Dyk D, Fazenbaker C, McGlinchey K, Luo W, Pezold JM, Meekin J, Chang CY, Carrasco RA, Breen S, Cheung CS, Endlich-Frazier A, Clark B, Chu NJ, Vantellini A, Martin PL, Hoover CE, Riley K, Sweet SM, Chain D, Kim YJ, Tu E, Harder N, Phipps S, Damschroder M, Gilbreth RN, Cobbold M, Moody G, Bosco EE. Zanvit P, et al. Among authors: hoover ce. J Clin Invest. 2023 Nov 15;133(22):e169655. doi: 10.1172/JCI169655. J Clin Invest. 2023. PMID: 37966111 Free PMC article.
Tumor-derived biomarkers predict efficacy of B7H3 antibody-drug conjugate treatment in metastatic prostate cancer models.
Agarwal S, Fang L, McGowen K, Yin J, Bowman J, Ku AT, Alilin AN, Corey E, Roudier MP, True LD, Dumpit R, Coleman I, Lee JK, Nelson PS, Capaldo BJ, Mariani A, Hoover C, Senatorov IS, Beshiri M, Sowalsky AG, Hurt EM, Kelly K. Agarwal S, et al. Among authors: hoover c. J Clin Invest. 2023 Nov 15;133(22):e162148. doi: 10.1172/JCI162148. J Clin Invest. 2023. PMID: 37725435 Free PMC article.
Session 5: Protein Degraders.
Palyada K, Hukkanen R, Leuenroth-Quinn S, Vitsky A, Peterson R, Stamp K, Hoover C, Volak L. Palyada K, et al. Among authors: hoover c. Toxicol Pathol. 2024 Dec;52(8):553-565. doi: 10.1177/01926233241300452. Epub 2024 Dec 11. Toxicol Pathol. 2024. PMID: 39660628 Review.
Vutrisiran in Patients with Transthyretin Amyloidosis with Cardiomyopathy.
Fontana M, Berk JL, Gillmore JD, Witteles RM, Grogan M, Drachman B, Damy T, Garcia-Pavia P, Taubel J, Solomon SD, Sheikh FH, Tahara N, González-Costello J, Tsujita K, Morbach C, Pozsonyi Z, Petrie MC, Delgado D, Van der Meer P, Jabbour A, Bondue A, Kim D, Azevedo O, Hvitfeldt Poulsen S, Yilmaz A, Jankowska EA, Algalarrondo V, Slugg A, Garg PP, Boyle KL, Yureneva E, Silliman N, Yang L, Chen J, Eraly SA, Vest J, Maurer MS; HELIOS-B Trial Investigators. Fontana M, et al. N Engl J Med. 2024 Aug 30. doi: 10.1056/NEJMoa2409134. Online ahead of print. N Engl J Med. 2024. PMID: 39213194
Timing of influenza antiviral therapy and risk of death in adults hospitalized with influenza-associated pneumonia, FluSurv-NET, 2012-2019.
Tenforde MW, Noah KP, O'Halloran AC, Kirley PD, Hoover C, Alden NB, Armistead I, Meek J, Yousey-Hindes K, Openo KP, Witt LS, Monroe ML, Ryan PA, Falkowski A, Reeg L, Lynfield R, McMahon M, Hancock EB, Hoffman MR, McGuire S, Spina NL, Felsen CB, Gaitan MA, Lung K, Shiltz E, Thomas A, Schaffner W, Talbot HK, Crossland MT, Price A, Masalovich S, Adams K, Holstein R, Sundaresan D, Uyeki TM, Reed C, Bozio CH, Garg S. Tenforde MW, et al. Among authors: hoover c. Clin Infect Dis. 2024 Aug 22:ciae427. doi: 10.1093/cid/ciae427. Online ahead of print. Clin Infect Dis. 2024. PMID: 39172994
322 results